A novel and efficient process for the preparation of zolpidem, an insomnia drug was written by Eswaraiah, P.;Ravi, Kumar Reddy N.;Chakravarthy, I. E.;Prasada, Rao D. E.;Rajendiran, C.. And the article was included in Journal of Chemical and Pharmaceutical Research in 2016.Recommanded Product: 106961-33-5 This article mentions the following:
Zolpidem, is an imidazopyridine group of non-benzodiazepine class drug, used for the treatment of insomnia. Here with presenting a new approach for the synthesis zolpidem without isolation of intermediates. The modified process is efficient, cost effective, simplified work up process and scalable synthesis of zolpidem with reducing cycle time. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5Recommanded Product: 106961-33-5).
N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine (cas: 106961-33-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Recommanded Product: 106961-33-5
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem