A regiospecific rearrangement of 4(5)-substituted 2-phenacylthio-1H-imidazoles to 4-substituted 2-mercapto-1-phenacyl-1H-imidazoles was written by Chakrabarti, Jiban K.;Smith, Colin W.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1991.Formula: C6H8N2O2S This article mentions the following:
4(5)-Substituted 2-phenacylthio-1H-imidazoles I (R = CO2Et, Ph) thermally rearrange to give 2-mercapto-1-phenacyl-1H-imidazoles II. In the experiment, the researchers used many compounds, for example, Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8Formula: C6H8N2O2S).
Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C6H8N2O2S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem