Synthesis of nitroimidazole substituted 3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioximes (propylene amine oximes, PnAOs): ligands for technetium-99m complexes with potential for imaging hypoxic tissue was written by Ramalingam, Kondareddiar;Raju, Natarajan;Nanjappan, Palaniappa;Nowotnik, David P.. And the article was included in Tetrahedron in 1995.COA of Formula: C5H5N3O4 This article mentions the following:
A series of 2-substituted-1,3-diaminopropanes have been synthesized as precursors to nitroimidazole-substituted 3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime (propylene amine oxime, PnAO) ligands. 3-Chloro-3-methyl-1-(2- or 4-nitro-1H-imidazol-1-yl)-2-nitrosobutanes required for the syntheses of nitroimidazole substituted PnAO ligands were prepared from the corresponding dimethylallylnitroimidazoles by the addition of nitrosyl chloride. A number of nitroimidazole derivatized PnAO ligands possessing potential for either electrostatic, hydrophobic, or hydrophilic interactions were synthesized as precursors to technetium-99m complexes under investigation as potential imaging agents of hypoxia. Derivatives of PnAO, substituted at carbon one, were prepared using the 3-chloro-3-methyl-1-(2- or 4-nitro-1H-imidazol-1-yl)-2-nitrosobutanes. Three PnAOs derivatized at the central carbon atom were prepared using 3-bromo-3-methylbutan-2-one. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7COA of Formula: C5H5N3O4).
2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. COA of Formula: C5H5N3O4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem