Design and Application of a Low-Temperature Continuous Flow Chemistry Platform was written by Newby, James A.;Blaylock, D. Wayne;Witt, Paul M.;Pastre, Julio C.;Zacharova, Marija K.;Ley, Steven V.;Browne, Duncan L.. And the article was included in Organic Process Research & Development in 2014.Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:
A flow reactor platform technol. applicable to a broad range of low temperature chem. is reported. The newly developed system captures the essence of running low temperature reactions in batch and represents this as a series of five flow coils, each with independently variable volume The system was initially applied to the functionalization of alkynes, Grignard addition reactions, heterocycle functionalization, and heteroatom acetylation. This new platform has then been used in the preparation of a 20-compound library of polysubstituted, fluorine-containing aromatic substrates from a sequential metalation-quench procedure and can be readily adapted to provide gaseous electrophile inputs such as carbon dioxide using a tube-in-tube reactor. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem