Effect of the rat liver S-9 fraction on the mutagenicity of azathioprine in the Salmonella/mammalian microsome assay was written by Nepomnaschy, I.;Sommer, S. E.;Nagel, R.. And the article was included in Experientia in 1984.Recommanded Product: 3034-41-1 This article mentions the following:
Azathioprine (I) [446-86-6] is a direct acting mutagen in S. typhimurium TA 100 and 1535. The addition of rat liver S-9 fraction with or without cofactors, or GSH [70-18-8], decreased the mutagenicity of I in TA 100 and increased in TA 1535, indicating the effect of SH groups. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 3034-41-1).
1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 3034-41-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem