Formulation & evaluation of spherical crystal agglomerates of Candesartan Cilexetil was written by Chaubisa, Prachi D.;Shah, S. K.;Chaudhary, Bhumika. And the article was included in World Journal of Pharmaceutical Research in 2018.Product Details of 145040-37-5 This article mentions the following:
A quasi-emulsion solvent diffusion method was adopted for preparation of spherical agglomerates of Candesartan Celexetil using Acetone as a good solvent and water as a poor solvent. Dichloromethane was added to the solution of Candesartan Cilexetil as Bridging liquid Preliminary trials were taken to identify significant factors affecting formation of spherical agglomerates. A 32 full factorial design was employed to study the effect of following independent variables at the three different levels on the characteristics of the product obtained. They are amount of PVA and amount of PEG 4000. Exptl. trials were performed at all possible 9 combinations in and the resultant product obtained was evaluated for parameters like saturation solubility, Hausner ratio, Carr’s index and amount of the drug dissolved in 180 min. Based on factorial design anal., it found that the selected factors having significant effect on % drug release. Tablets prepared by using optimized spherical crystal agglomerates of F4 batch and evaluation done. All phys. parameters found within acceptable range. Further the dissolution of tablets in 180 min found more than 90% which was also compared with marketed formulation. The release kinetic model found most satisfactory with Higuchi Model. Stability of spherical crystal agglomerates Tablets of Candesartan Cilexetil found stable after 1 mo. Hence, spherical crystal agglomerates of Candesartan Cilexetil successfully prepared by quasi-emulsion solvent diffusion method and solubility improved. Further based on the results. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Product Details of 145040-37-5).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 145040-37-5
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem