Formulation and In Vitro, In Vivo Correlation Between Two Candesartan Cilexetil Tablets was written by Zaid, Abdel Naser;Radwan, Asma;Jaradat, Nidal;Mousa, Ayman;Ghazal, Nadia;Bustami, Rana. And the article was included in Clinical Pharmacology in Drug Development in 2018.HPLC of Formula: 145040-37-5 This article mentions the following:
In this study, the in vitro and in vivo interchangeability between generic candesartan 16 mg and the branded formulation was assessed. The in vitro release of these products was conducted in 3 pH media (1.2, 5.0, and 6.8), and similarity factors (f2) were calculated This bioequivalence study was a randomized, 2-period crossover study that included 42 healthy adult male subjects under fasting conditions with a 9-day washout. The pharmacokinetic (PK) parameters AUC0-last, AUC0-∞, and Cmax, tmax, and the elimination half-life time were assessed based on the plasma concentrations of candesartan, using a newly developed and validated liquid chromatog.-tandem mass spectrometry bioanal. method with acceptable degrees of linearity, sensitivity, precision, and accuracy. The geometric mean (ng.h/mL) of the AUC0-∞ for the test and brand was 1595.49 and 1620.54, resp., and the Cmax (ng/mL) was 160.91 and 160.88, resp. The 90%CIs of geometric mean ratios (test-to-reference ratios) were 98.26%, 98.45%, and 99.86% for AUC0-last, AUC0-∞, and Cmax resp. These PK parameters lie within the US Food and Drug Administration- and European Medicines Agency-specified bioequivalence limit (80%-125%). Both products were well tolerated by all the subjects. The tested drug product was bioequivalent to the reference drug and had the same safety profile. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5HPLC of Formula: 145040-37-5).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.HPLC of Formula: 145040-37-5
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem