Halide-Free Continuous Synthesis of Hydrophobic Ionic Liquids was written by Stagel, Kristof;Szpecht, Andrea;Zielinski, Dawid;Smiglak, Marcin;Schnuerch, Michael;Bica-Schroeder, Katharina. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:
A novel approach for the halide-free, continuous-flow preparation of hydrophobic ionic liquids (ILs) relying on the bis(trifluoromethanesulfonyl)imide (bistriflimide, NTf2–) anion. The simple yet fast two-step synthetic route, which involved the formation of different alkyl bistriflimides (RNTf2), followed by the quaternization with an amine nucleophile, led to the desired ILs in high yields and excellent purities without any byproduct formation. The variable alkyl chain (R) length and the broad range of the applicable nucleophiles offer considerable flexibility to the synthetic protocol. The quaternization could be performed under solvent-free conditions; moreover, the homogeneous nature of these reactions allowed the application of modern continuous-flow technologies. Given these advantages, the methodol. could afford not just a fast and efficient alternative for the conventional synthesis of such compounds with reduced waste water production but their negligible halide content might provided a significantly broader application range of the IL products, especially for the field of materials science. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).
3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem