Synthesis of the anti-hypertensive drug olmesartan medoxomil in greener approach was written by Shanker, Ch. Gouri;Sujitha, D.;Kumar, D. Aravind;Sudhakar, K.. And the article was included in Heterocyclic Letters in 2018.Reference of 145040-37-5 This article mentions the following:
Proton and metal ion-exchanged Montmorillonite and Copper-Aluminum Hydroxyapatite (Cu-HAP) catalysts were effectively used in the esterifiaction, C-N bond formation and Detritylation in methanol efford Olmesartan Medoxomil in good yields. The catalysts were quant. recovered from reaction mixture by simple filtration and reused for four cycles with consistent activity. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Reference of 145040-37-5).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Reference of 145040-37-5
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem