The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2 was written by D’Alessandro, Pier L.;Corti, Corrado;Roth, Adelheid;Ugolini, Annarosa;Sava, Anna;Montanari, Dino;Bianchi, Federica;Garland, Stephen L.;Powney, Ben;Koppe, Emma L.;Rocheville, Magalie;Osborne, Greg;Perez, Paloma;de la Fuente, Jesus;De Los Frailes, Maite;Smith, Paul W.;Branch, Clive;Nash, David;Watson, Stephen P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.HPLC of Formula: 3012-80-4 This article mentions the following:
The optimization of an HTS hit series (1) leading to the identification of structurally novel, selective, orally bioavailable mGluR2 pos. modulators GSK1331258 and GSK1331268 is described. Structure-activity relationships, attenuation of dopaminergic activity, and potentiation of mGluR2 responses in rat hippocampal MPP-DG synapses are also reported. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4HPLC of Formula: 3012-80-4).
1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 3012-80-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem