Toxicity of nitro compounds toward hypoxic mammalian cells in vitro: dependence on reduction potential was written by Adams, G. E.;Stratford, I. J.;Wallace, R. G.;Wardman, P.;Watts, M. E.. And the article was included in JNCI, Journal of the National Cancer Institute in 1980.Synthetic Route of C5H5N3O4 This article mentions the following:
Fifteen nitroarom. and nitroheterocyclic compounds that can act as radiosensitizers were tested for their cytotoxicity toward hypoxic Chinese hamster V79 cells in vitro. The cytotoxicity increased markedly as the electron affinity, measured as a one-electron reduction potential, increased. Nonnitro compounds of similar electron affinities (such as quinones) that also act as radiosensitizers did not exhibit this specific toxicity toward hypoxic cells. The implications of the presence of the nitro group as a prerequisite for the hypoxic cell toxicity are discussed, and the mechanism of the cytotoxicity was compared with that of hypoxic cell radiosensitization. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Synthetic Route of C5H5N3O4).
2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Synthetic Route of C5H5N3O4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem