Month: January 2023

Efficient and convenient oxidation of sulfides to sulfones using H₂O₂ catalyzed by V₂O₅ in ionic liquid [C₁₂mim][HSO₄] was written by Hu, Yu-Lin;Liu, Xiao-Bing;Fang, Dong. And the article was included in Catalysis Science & Technology in 2014.Electric Literature of C18H31F6N3O4S2 This article mentions the following:

A simple, efficient, and eco-friendly procedure for the oxidation of sulfides to sulfones using H₂O₂ catalyzed by V₂O₅ in ionic liquid [C₁₂mim][HSO₄] has been developed. This atom-economical protocol affords the target products in good to high yields. The products can be separated by a simple extraction with organic solvent, and the catalytic system can be recycled and reused without loss of catalytic activity. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Electric Literature of C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product control by halide ions of ionic liquids in the ionothermal syntheses of Ni-(H)BTC metal-organic frameworks was written by Xu, Ling;Yan, Shihai;Choi, Eun-Young;Lee, Jin Yong;Kwon, Young-Uk. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2009.Quality Control of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Ni(OAc)₂-H₃BTC (1,3,5-benzenetricarboxylic acid) system in various imidazolium ionic liquids, [RMI]X (R = Et, Pr, n-butyl; X = Cl, Br, I), produced five MOFs in two structure types; [RMI]₂[Ni₃(BTC)₂(OAc)₂] and [RMI]₂[Ni₃(HBTC)₄(H₂O)₂][RMI]₂. Their relative thermodn. stability varies with the cation size of RMI⁺, and the X^– ions govern the kinetic factors so that their combination effects determine the final product. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Quality Control of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Quality Control of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of 5-fluorouracil, ftorafur and imidazolecarboxamide on the kinetics of the primary immune response in mice was written by Matveev, A. B.;Kudryashov, V. M.. And the article was included in Farmakologiya i Toksikologiya (Moscow) in 1981.SDS of cas: 26832-08-6 This article mentions the following:

Treatment of mice with 5-fluorouracil [51-21-8], ftorafur [17902-23-7], or imidazolecarboxamide [26832-08-6] at 48 or 72 h following immunization with sheep erythrocytes caused an oscillatory-type of response in splenic antibody-forming cells. Each pattern of increases-decreases lasted 8-16 h. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6SDS of cas: 26832-08-6).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 26832-08-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formulation and development of candesartan cilexetil fast dissolving tablets by sublimation technique was written by Priya, Hunashal Sarah;Patil, Basawaraj S.;Jeevanagi, Ravindra S.. And the article was included in American Journal of PharmTech Research in 2019.Reference of 145040-37-5 This article mentions the following:

Candesartan cilexetil is a prodrug of candesartan – a compound that inhibits binding of angiotensin II to the AT1 – receptor. It is mainly used in the treatment of hypertension. In the present work attempts were mase to prepare fast dissolving tablets of candesartan cilexetil by sublimation technique. The prepared formulations were evaluated for pre-compressional and postcompressional parameters. The compatibility of drug with other ingredients was checked by FTIR studies, these results revealed that there was no interaction between dug and other excipients. The values of pre-compressional parameters were within prescribed limits and indicated good free flowing properties. In all the formulations the hardness test indicates good mech. strength. Friability of all formulations was less than 1. Drug content was found to be high (≥ 100.27%) and uniform in all the formulations. The tablet thickness was found to be 3.14 – 3.47. The weight variation results revealed that average percentage deviation was less then ± 7.5%, which provides good uniformity in all formulations. The disintegration time of the tablets decreased significantly with increase in the concentration of subliming agent. The formulations CSC3, CSM3, CSA3, and CSU3 50% of drug released in 1.38, 2.55, 4.00 and 3.57 min, and 90% of drug released in 3.39, 6.04, 7.50 and 7.18 min. The formulation CS (control) released 42.16% in 60 min. Stability study carried out as per ICH guidelines for three months and results revealed that upon storage disintegration time of tablets decreased significantly (p<0.05). The results concluded that by adopting a systemic formulation approach, an optimum point could be reached in the shortest time with min. efforts. Sublimation technique would be an effective alternative approach compared with the use of more expensive adjuvants in the formulations of fast dissolving tablets. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Reference of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cobalt(II)/(imidazoline-oxazoline)-catalyzed enantioselective Michael addition of 2-acetyl azaarenes to β-CF₃-β-disubstituted nitroalkenes was written by Hao, Xin-Qi;Wang, Cong;Liu, Shuang-Liang;Wang, Xiao;Wang, Li;Gong, Jun-Fang;Song, Mao-Ping. And the article was included in Organic Chemistry Frontiers in 2017.COA of Formula: C6H8N2O This article mentions the following:

A series of chiral (imidazoline-oxazoline) N,N-bidentate ligands derived from 2,2-dimethylmalonic acid were conveniently synthesized and characterized. With the aid of the new ligands, the first Co(II)-catalyzed asym. Michael addition of 2-acetyl azaarenes to β-CF₃-β-disubstituted nitroalkenes was successfully achieved, producing chiral compounds with a trifluoromethylated all-carbon quaternary stereocenter in good yields with enantioselectivities of up to 98% ee. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1COA of Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of [¹⁸F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)acetamide], a marker for PET detection of hypoxia was written by Josse, Olivier;Labar, Daniel;Georges, Benoit;Gregoire, Vincent;Marchand-Brynaert, Jacqueline. And the article was included in Bioorganic & Medicinal Chemistry in 2001.Application of 22813-32-7 This article mentions the following:

[¹⁸F]-2-(2-Nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)acetamide ([¹⁸F]-EF3) has been prepared in 65% chem. yield and 5% radiochem. yield by coupling 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl)acetate with [¹⁸F]-3,3,3-trifluoropropylamine. This original radiolabeled key synthon was obtained in 40% overall chem. yield by oxidative [¹⁸F]-fluorodesulfurization of Et N-phthalimido-3-aminopropanedithioate, followed by deprotection with hydrazine of the resulting [¹⁸F]-N-phthalimido-3,3,3-trifluoropropylamine. The process was performed within 90 min, from the [¹⁸F]-HF production in the cyclotron to the purification of the final target. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Application of 22813-32-7).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 22813-32-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine was written by Mukherjee, Arijit;Rogers, Robin D.;Myerson, A. S.. And the article was included in CrystEngComm in 2018.Product Details of 404001-48-5 This article mentions the following:

Liquid assisted grinding using imidazolium-based ionic liquids (IL-AG) was found to be effective in isolation of cocrystals and cocrystal polymorphs. Isolation of specific polymorphs of caffeine-citric acid (CAF-CA) and caffeine-glutaric acid (CAF-GLU) cocrystals highlights the tunability of ILs in polymorphic control. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Product Details of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cluster approach to the prediction of thermodynamic and transport properties of ionic liquids was written by Seeger, Zoe L.;Kobayashi, Rika;Izgorodina, Ekaterina I.. And the article was included in Journal of Chemical Physics in 2018.Name: 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

The prediction of physicochem. properties of ionic liquids such as conductivity and m.p. would substantially aid the targeted design of ionic liquids for specific applications ranging from solvents for extraction of valuable chems. to biowaste to electrolytes in alternative energy devices. The previously published study connecting the interaction energies of single ion pairs (1 IP) of ionic liquids to their thermodn. and transport properties has been extended to larger systems consisting of two ion pairs (2 IPs), in which many-body and same-ion interactions are included. Routinely used cations, of the imidazolium and pyrrolidinium families, were selected in the study coupled with chloride, tetrafluoroborate, and dicyanamide. Their two ion pair clusters were subjected to extensive configuration screening to establish most stable structures. Interaction energies of these clusters were calculated at the spin-ratio scaled MP2 (SRS-MP2) level for the correlation interaction energy, and a newly developed scaled Hartree-Fock method for the rest of energetic contributions to interaction energy. A full geometry screening for each cation-anion combination resulted in 192 unique structures, whose stability was assessed using two criteria-widely used interaction energy and total electronic energy. Furthermore, the ratio of interaction energy to its dispersion component was correlated with exptl. observed m.ps. in 64 energetically favorable structures. These systems were also used to test the correlation of the dispersion contribution to interaction energy with measured conductivity (c) 2018 American Institute of Physics. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Name: 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Name: 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chemical Modification of siRNA Bases To Probe and Enhance RNA Interference was written by Peacock, Hayden;Kannan, Arunkumar;Beal, Peter A.;Burrows, Cynthia J.. And the article was included in Journal of Organic Chemistry in 2011.Synthetic Route of C8H8N2 This article mentions the following:

Considerable attention has focused on the use of alternatives to the native ribose and phosphate backbone of small interfering RNAs for therapeutic applications of the RNA interference pathway. In this synopsis, we highlight the less common chem. modifications, namely, those of the RNA nucleobases. Base modifications have the potential to lend insight into the mechanism of gene silencing and to lead to novel methods to overcome off-target effects that arise due to deleterious protein binding or mis-targeting of mRNA. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Synthetic Route of C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Synthetic Route of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis, Characterization, Thermal Analyses, and Spectroscopic Properties of Novel Naphthyl-Functionalized Imidazolium Ionic Liquids was written by Yao, Meihuan;Li, Qing;Xia, Yanqiu;Liang, Yongmin. And the article was included in Russian Journal of Physical Chemistry A in 2018.Product Details of 21252-69-7 This article mentions the following:

A series of novel ionic liquids based on naphthyl-functionalized imidazolium cation have been prepared Their structure was characterized by NMR. The thermal stabilities of the prepared liquids were studied by thermal gravimetric anal. The new ionic liquids containing NTf₂^– anion display significantly higher thermal stabilities (> 400°C). Anion exchange to PF₆^–, BF₄^–, and Br^– decreases the thermal stabilities of such ionic liquids Fluorescence and UV-Vis absorption spectroscopy were used to study the spectroscopic properties of the ionic liquids Compared with common ionic liquids, the described ionic liquids provide robust fluorescence properties and remarkably increased UV-Vis absorption. This research may enrich the field of functionalized ionic liquids and provide a platform for extension of ionic liquid applications. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Product Details of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem