Month: January 2023

Fluorescence Enhancement of Imidazolium Ionic Liquid by Its Confinement on PVC for In Situ Selective Quantification of Hemoglobin was written by Shu, Yang;Han, Lu;Wang, Xiaofeng;Chen, Xuwei;Wang, Jianhua. And the article was included in ACS Applied Materials & Interfaces in 2013.Computed Properties of C4H7ClN2 This article mentions the following:

A hydrophilic ionic liquid (methylimidazolium chloride, NmimCl)-polyvinyl chloride ionomer (NmimCl-PVC) was prepared by immobilizing and confining N-methylimidazole onto PVC chains. The NmimCl-PVC ionomer exhibits a 4-fold enhancement on the fluorescence intensity with respect to that of NmimCl, attributing to the confinement of ionic liquid by the PVC chain. The fluorescence is excitation-dependent with a maximum at λ_em430 nm when excited at 325 nm. In addition, the fluorescence intensity of NmimCl-PVC ionomer increases remarkably with the loading ratio of N-methylimidazole in the range of 4.3-15.1%. The fluorescence quantum yield and lifetime were derived to be 0.112/7.1 ns for the NmimCl-PVC ionomer and 0.063/8.8 ns for NmimCl. Furthermore, Hb is selectively adsorbed by NmimCl-PVC and causes significant fluorescence quenching of the ionomer via dynamic quenching and energy transfer between NmimCl-PVC and Hb. A solid surface fluorimetric procedure was developed for surface adsorption and preconcentration of Hb followed by in situ detection. A linear dynamic range of 0.3-26.2 μg mg^-1 is achieved with a detection limit of 0.1 μg mg^-1. Regarding Hb in aqueous solution, the linear range 5-300 μg mL^-1 is achieved along with a detection limit of 2 μg mL^-1. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Computed Properties of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Computed Properties of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Potential radiosensitizing agents. 5. 2-Substituted benzimidazole derivatives was written by Gupta, Rajender P.;Larroquette, Cynthia A.;Agrawal, Krishna C.. And the article was included in Journal of Medicinal Chemistry in 1982.Formula: C9H9N3 This article mentions the following:

Benzimidazoles I [R = CH₂CH(OH)CH₂OMe, CH₂CO₂Et; R¹ = CONH₂, Ac, CF₃, CN, SO₂Me, NO₂; R², R³ = H, NO₂] were prepared, e.g., by alkylation of I (R = H) with 1,2-epoxy-3-methoxypropane in the presence of K₂CO₃. Reaction of I (R¹ = NO₂, SO₂Me) with the epoxide also yielded a benzimidazo[2,1-b]oxazole derivative I (R¹ = NO₂) showed the highest radiosensitizing activity against Chinese hamster cells (V-79) in culture. In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Formula: C9H9N3).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Formula: C9H9N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Diversification of imidazo[1,2-a]pyridines under microwave-assisted palladium-catalyzed Suzuki reaction was written by Lee, Jin-Hee;Park, Seung Yeong;Park, Areum;Yum, Eul Kgun. And the article was included in Journal of the Korean Chemical Society in 2017.Category: imidazoles-derivatives This article mentions the following:

Diversified synthesis of arylated imidazo[1,2-a]pyridines I [R = H, CF₃, C₆H₅, 4-FC₆H₄; R¹ = H, 5-(pyridin-4-yl), 6-(4-H₃COC₆H₄), 7-C₆H₅, etc.; R² = H, C₆H₅, 4-H₃COC₆H₄, 2H-1,3-benzodioxol-5-yl, etc.] via microwave-assisted palladium-catalyzed Suzuki reaction of various bromoimidazo[1,2-a]pyridines II (X = H, 5-Br, 6-Br, 7-Br; Y = H, Br) with substituted arylboronic acids such as pyridin-4-ylboronic acid, (4-ethoxyphenyl)boronic acid, 2H-1,3-benzodioxol-5-ylboronic acid, etc. was described. In the experiment, the researchers used many compounds, for example, 5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1Category: imidazoles-derivatives).

5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recyclable bifunctional aluminum salen catalyst for CO₂ fixation: the efficient formation of five-membered heterocyclic compounds was written by Luo, Rongchang;Yang, Zhi;Zhang, Wuying;Zhou, Xiantai;Ji, Hongbing. And the article was included in Science China: Chemistry in 2017.Reference of 21252-69-7 This article mentions the following:

A variety of unique Al(salen) complexes functionalized by imidazolium-based ionic liquid (IL) moieties with the salen ligand at the two sides of 3,3′-position have been successfully prepared, rather than familiar 5,5′-position reported previously. The catalytic activity obtained by these bifunctional catalysts could be superior to those of the binary type catalysts in the formation of five-membered heterocyclic compounds from the cycloaddition reaction of CO₂ and three-membered heterocyclic compounds (including terminal epoxides and N-substituted aziridines), presumably due to the distinguished intramolecularly synergistic catalysis, which might lead to perform the cycloaddition reaction at ambient conditions and retain excellent yield and unprecedented chemo- or regioselectivity. Moreover, the polyether-based trifunctional Al(salen) catalysts with the best catalytic performance could be regenerated and reused at least eight times without any obvious decreases in catalytic activity. Finally, the kinetic investigation suggested the structure of catalysts had important influences on the catalytic activity, thereby proposing the possible reaction mechanism. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Self-assembly of sodium 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoate into ultralong microbelts was written by Zhao, Hongyan;Chen, Hongbiao;Gao, Yong;Li, Huaming. And the article was included in CrystEngComm in 2014.Application In Synthesis of 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid This article mentions the following:

In this study, a self-assembly technique is developed to fabricate ultralong microbelts of sodium 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoate (SDB). The as-prepared SDB microbelts have a belt-like structure with a rectangular cross section. All of the obtained microbelts under the optimum conditions have a relatively uniform size of about 5 μm in width, 2 μm in thickness, and approx. 5 mm in length. Particularly, the length of the SDB microbelts can be readily controlled by adjusting the SDB concentration as well as the aging temperature In addition, the optical and elec. properties of the as-prepared microbelts are also investigated. These results should be significant in triarylimidazole derivatives crystallization and their potential application in optoelectronic devices. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Application In Synthesis of 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application In Synthesis of 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A multi-residue method by supercritical fluid chromatography coupled with tandem mass spectrometry method for the analysis of chiral and non-chiral chemicals of emerging concern in environmental samples was written by Rice, Jack;Lubben, Anneke;Kasprzyk-Hordern, Barbara. And the article was included in Analytical and Bioanalytical Chemistry in 2020.Related Products of 145040-37-5 This article mentions the following:

Abstract: This manuscript presents the development, validation and application of a multi-residue supercritical fluid chromatog. coupled with tandem mass spectrometry method for the anal. of 140 chiral and non-chiral chems. of emerging concern in environmental samples, with 81 compounds being fully quant., 14 semi-quant. and 45 qual., validated according to European Medicine Agency (EMA) guidelines (European Medicines Agency 2019). One unified LC-MS method was used to analyze all analytes, which were split into three injection methods to ensure sufficient peak resolution The unified method provided an average of 113% accuracy and 4.5% precision across the analyte range. Limits of detection were in the range of 35 pg L^-1-0.7 μg L^-1, in both river water and wastewater, with an average LOD of 33 ng L^-1. The method was combined with solid-phase extraction and applied in environmental samples, showing very good accuracy and precision, as well as excellent chromatog. resolution of a range of chiral enantiomers including beta-blockers, benzodiazepines and antidepressants. The method resulted in quantification of 75% of analytes in at least two matrixes, and 56% in the trio of environmental matrixes of river water, effluent wastewater and influent wastewater, enabling its use in monitoring compounds of environmental concern, from their sources of origin through to their discharge into the environment. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Related Products of 145040-37-5).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Related Products of 145040-37-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Inhibition of guanine deaminase with derivatives of imidazole was written by Kanzawa, Fumihiko;Hoshi, Akio;Kuretani, Kazuo. And the article was included in Chemical & Pharmaceutical Bulletin in 1971.Category: imidazoles-derivatives This article mentions the following:

Inhibition of guanine deaminase by derivatives of 5-amino-4-imidazole-carboxamide (I) was studied. The 5-chloro derivative (II) was the most inhibitory among the halogen derivatives, but was less effective than I. 4-Imidazolecarboximide (III) was the most potent inhibitor found, more active even than I. Imidazole itself was a weak inhibitor. The Et ester instead of the amide, and the 5-chloro-6-carboxamidoxime derivatives were less effective than I, and the 4,5-dicarboxylic acid derivative was almost inactive. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Category: imidazoles-derivatives).

1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Anions as Dynamic Probes for Ionic Liquid Mixtures was written by Di Pietro, Maria Enrica;Castiglione, Franca;Mele, Andrea. And the article was included in Journal of Physical Chemistry B in 2020.Reference of 404001-48-5 This article mentions the following:

Ionic liquid (IL) mixtures were proposed as a viable alternative to rationally fine-tune the physicochem. properties of ILs for a variety of applications. The understanding of the effects of mixing ILs on the properties of the mixtures is however only in the early stages. Two series of ionic liquid mixtures, based on the 1-ethyl-3-methylimidazolium and 1-dodecyl-3-methylimidazolium cations, and having a common anion (tetrafluoroborate or bis(trifluoromethylsulfonyl)imide), were prepared and deeply characterized via multiple NMR techniques. Diffusion and relaxation methods combined with 2D ion-ion correlation (nuclear Overhauser enhancement) experiments were used for a better understanding of the interplay between dynamics and structure of IL mixtures A crucial role of the anion in driving the mixture’s behavior emerged, making them important “dynamic probes” for gaining information of the polar and nonpolar regions of ionic liquids and their mixtures In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Reference of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Reference of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A strategy of stabilization via active energy-exchange for bistable electrochromic displays was written by Gu, Chang;Wang, Xiaojun;Jia, Ai-Bo;Zheng, Hongzhi;Zhang, Weiran;Wang, Yuyang;Li, Minjie;Zhang, Yu-Mo;Zhang, Sean Xiao-An. And the article was included in CCS Chemistry in 2022.Computed Properties of C9H15F6N2P This article mentions the following:

As future energy-saving optoelectronics, bistable electrochromic (EC) materials/devices have high energy efficiency for potential applications as smart windows, displays, and information/energy storage, due to their ability to maintain optical states without consuming energy. However, further development is hindered by the lack of in-depth understanding of related key factors and universally applicable design strategies to achieve bistability. Herein, we report a new strategy based on active energyexchange with the aid of proton-coupled electron transfer, which can dynamically adjust the HOMO /LUMO energy levels of materials to obtain good bistability from traditional nonbistable materials. This strategy was thoroughly studied and proven by taking quinone derivatives and bromocresol green derivatives as examples. The device obtained after further polymerization and optimization showed remarkable bistability, coloration efficiency, and application potential for energy-saving flexible displays. The success, challenges, and cognitive gains of this strategy not only accelerate the development of various energysaving optoelectronic materials/devices, but are also likely to stimulate progress in physics, chem., and materials. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9Computed Properties of C9H15F6N2P).

1-Butyl-3-vinyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 915358-85-9) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C9H15F6N2P

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Asymmetric α-Functionalization of 2-Alkyl Azaarenes: Synthesis of Tertiary Fluorides Having Vicinal Stereogenic Centers was written by Das, Arko;Joshi, Harshit;Singh, Vinod K.. And the article was included in Organic Letters in 2021.Electric Literature of C6H8N2O This article mentions the following:

An enantioselective approach for synthesizing fluorinated azaarenes containing vicinal quaternary-tertiary stereocenters I [R¹ = Ph, CH=CHPh, 2-thienyl, etc.; R² = Me, OMe, OEt, Ph; R³ = 2-pyridyl, benzo[d]thiazol-2-yl] was summarized. The chiral copper(I)-phosphine complex binded with the azaarenes followed by Michael addition to unsaturated acyl imidazoles, resulting in α-functionalized products with an excellent level of enantioselectivities (up to 99%), diastereoselectivities (>20:1), and yields (up to 97%). Furthermore, post-functionalization of the acyl imidazole part had also been demonstrated. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Electric Literature of C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem