Month: January 2023

The effects of structural changes on the anti-microbial and anti-proliferative activities of diimidazolium salts was written by Cancemi, Patrizia;Buttacavoli, Miriam;D’Anna, Francesca;Feo, Salvatore;Fontana, Rosa Maria;Noto, Renato;Sutera, Alberto;Vitale, Paola;Gallo, Giuseppe. And the article was included in New Journal of Chemistry in 2017.Formula: C11H20N2 This article mentions the following:

An array of diimidazolium salts has been synthesized and used to investigate their anti-microbial and anti-proliferative activities. In particular, salts based on the 3,3′-di-n-alkyl-1,1′-(1,n-phenylenedimethylene)diimidazolium cation and differing in the alkyl chain length on the imidazolium ion, the isomeric substitution on the aromatic spacer and in the anion nature were used. The anti-proliferative activity was evaluated against cervical (HeLa), colon adenocarcinoma (HT-29) and breast (SKBR3) cancer cell lines. In the latter case, also a morphol. assessment after treatment with salts was performed. All salts were tested for their hemolytic activity against human erythrocytes. On the other hand, the anti-microbial activity was investigated using both Gram-neg. (Escherichia coli) and Gram-pos. (Kokuria rhizophila, Staphylococcus aureus and Bacillus subtilis) strains. On the whole, the data collected demonstrate that biol. activity is the result of the combined action of both cation and anion structures. In general, the cation hydrophobicity plays the most significant role with structural features of the anion becoming more relevant in the presence of a shorter alkyl chain on the cationic head. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Formula: C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Formula: C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In situ generation of hydrophobic magnetic ionic liquids in stir bar dispersive liquid-liquid microextraction coupled with headspace gas chromatography was written by Trujillo-Rodriguez, Maria J.;Anderson, Jared L.. And the article was included in Talanta in 2019.Reference of 21252-69-7 This article mentions the following:

For the first time, an in situ stir bar dispersive liquid-liquid microextraction approach has been developed and coupled with headspace gas chromatog.-mass spectrometry for the determination of a group of organic pollutants. The method exploits a new generation of magnetic ionic liquids (MILs) that contain paramagnetic cations based on Ni²⁺ or Co²⁺ metal centers coordinated with either N-butylimidazole or N-octylimidazole ligands and chloride anions. The reactants are added to an aqueous solution containing a high field neodymium rod magnet, followed by the addition of the bis[(trifluoromethyl)sulfonyl]imide anion that promotes a metathesis reaction for the in situ generation of a hydrophobic MIL. Concurrently, a high stirring rate is maintained to exceed the magnetic field of the rod magnet and disperse the generated MIL in the sample solution When stirring is stopped, the MIL coats the rod magnet due to its paramagnetic nature, facilitating the MIL transfer and subsequent desorption and anal. Under optimum conditions, the method required a 2.5-18% (w/v) aqueous solution of sodium chloride, 10 mL of sample, 20 or 30 mg of MIL, the addition of a small volume of dispersive solvent, and stirring for 5-7.5 min, depending on the MIL. The method provided limits of detection (LODs) down to 10μg L^-1, adequate reproducibility (with relative standard deviation values lower than 10% for a spiked level of 80μg L^-1), and relative recoveries between 72.5% and 102%. Furthermore, the method was successfully applied in the anal. of tap and mineral water. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic PMMA/nanosilica interfaces from grafting ionic liquids under supercritical CO₂ conditions was written by Fedosse Zornio, Clarice;Livi, Sebastien;Jestin, Jacques;Duchet, Jannick;Gerard, Jean-Francois. And the article was included in European Polymer Journal in 2018.Product Details of 21252-69-7 This article mentions the following:

Supercritical carbon dioxide (scCO₂) was considered as an environmental friendly medium for grafting the surface of silica nanoparticles with a series of reactive imidazolium-based ionic liquids (IL), denoted as IL-silanes. The effects of the reaction conditions on the resulting IL-grafted layers on the silica surface were characterized from thermogravimetric (TGA) and transmission electronic microscopy (TEM) analyses. The IL-grafted nanoparticles were introduced into poly(Me methacrylate) (PMMA) via melt mixing in order to design nanocomposites and to demonstrate the ability of IL-grafted nanoparticles to be dispersed into a polymer medium. The role of the IL-grafted surfaces on the morphol. of PMMA-based nanocomposites was evidenced by TEM and small angle neutron scattering (SANS). It was demonstrated that longer the alkyl chain length of the IL-silane, better the state of dispersion of nanoparticles within PMMA. In addition, better thermal stabilities and mech. performances, as well as new surface properties were observed for the designed PMMA-based nanocomposites. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Product Details of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Product Details of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

All-Solid-State Polymer Electrolyte with Efficiency and Stability Superior to Its Smectic Precursor for Photoelectrochemical Devices was written by Zhou, Jiwen;Wang, Caihong;Zhang, Xiaoqian;Luo, Jie;Ji, Junyi;Wu, Yong;Tan, Shuai. And the article was included in Industrial & Engineering Chemistry Research in 2021.Category: imidazoles-derivatives This article mentions the following:

All-solid-state electrolytes have attracted wide interest for versatile energy devices owing to their stability improvement toward sustainable applications; however, the low conductivity and interfacial contact remain to be addressed. Herein, a facile method was proposed for preparing superior all-solid-state electrolytes from ionic liquid crystals. A vinylimidazolium thiolate/disulfide redox-based lamellar nanostructured electrolyte showing a smectic mesophase was prepared as a precursor, and flexible polyethylene oxide (PEO) was introduced to gel the smectic domains of the precursor to form a microphase segregation nanostructure. The PEO chains assembled at domain interfaces could significantly improve the charge transport through the smectic domain boundaries in the electrolyte. The dynamic liquid crystal gel was first assembled in a dye-sensitized solar cell (DSSC) to provide good interfacial contact, and then, in situ polymerization was performed to fabricate an all-solid-state electrolyte. The microphase segregation nanostructure was well maintained within the polymerized electrolytes for efficient charge transport. Thus, the all-solid-state electrolytes exhibited ion conductivity, thermal stability, and DSSC efficiency much superior to its smectic precursor despite the loss of fluidity. The work here sheds new light on developing desirable all-solid-state electrolytes from ionic liquid crystals for energy devices. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Category: imidazoles-derivatives).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and properties of amides of 2-[(4-methylphenyl)(2-thienylsulfonyl)amino]acetic acid was written by Tyuneva, I. V.;Filimonov, S. I.;Balakin, K. V.;Skorenko, A. V.;Kravchenko, D. V.;Dorogov, M. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2004.Recommanded Product: 24134-26-7 This article mentions the following:

A series of [(4-methylphenyl)(2-thienylsulfonyl)amino]acetamides I (R¹ = H, R² = cyclopentyl, 2-ClC₆H₄CH₂, PhCHMe, 4-ClC₆H₄CH₂CH₂, etc.; R¹R²N = 4-benzyl-1-piperidinyl, 2,3-dihydro-1-indolyl, etc.) was synthesized by reaction of 2-thiophenesulfonyl chloride with Me (4-methylphenylamino)acetate followed by the ether group hydrolysis and amination with various primary and secondary amines. Some important physico-chem. properties of I, such as partition coefficient, solubility, amount of non-terminal rotating bonds and the total number of hydrogen bond donors and acceptors, were calculated In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Recommanded Product: 24134-26-7).

2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 24134-26-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sustainable Production of o-Xylene from Biomass-Derived Pinacol and Acrolein was written by Hu, Yancheng;Li, Ning;Li, Guangyi;Wang, Aiqin;Cong, Yu;Wang, Xiaodong;Zhang, Tao. And the article was included in ChemSusChem in 2017.COA of Formula: C7H13ClN2 This article mentions the following:

O-Xylene (OX) is a large-volume commodity chem. that is conventionally produced from fossil fuels. In this study, an efficient and sustainable two-step route is used to produce OX from biomass-derived pinacol and acrolein. In the first step, the phosphotungstic acid (HPW)-catalyzed pinacol dehydration in 1-ethyl-3-methylimidazolium chloride ([emim]Cl) selectively affords 2,3-dimethylbutadiene. The high selectivity of this reaction can be ascribed to the H-bonding interaction between Cl^– and the hydroxy group of pinacol. The stabilization of the carbocation intermediate by the surrounding anion Cl^– may be another reason for the high selectivity. Notably, the good reusability of the HPW/[emim]Cl system can reduce the waste output and production cost. In the second step, OX is selectively produced by a Diels-Alder reaction of 2,3-dimethylbutadiene and acrolein, followed by a Pd/C-catalyzed decarbonylation/aromatization cascade in a one-pot fashion. The sustainable two-step process efficiently produces renewable OX in 79 % overall yield. Analogously, biomass-derived crotonaldehyde and pinacol can also serve as the feedstocks for the production of 1,2,4-trimethylbenzene. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8COA of Formula: C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.COA of Formula: C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis and Radiosynthesis of Prospective 2-Nitroimidazole Hypoxia PET Tracers via Thiazolidine Ligation with 5-Fluorodeoxyribose (FDR) was written by Musolino, M.;Dall’Angelo, S.;Zanda, M.. And the article was included in SynOpen in 2017.Electric Literature of C5H5N3O4 This article mentions the following:

The first prospective fluorinated PET tracers for imaging hypoxia obtained via thiazolidine-ligation are reported. Three 1,2-thiol-amine linkers were combined with four different 2-nitroimidazole spacers via amide or urea bond formation. The resulting compounds, e.g., I were submitted to thiazolidine-ring-forming ligation reaction with the fluorinated carbohydrate L-5-fluoro-5-deoxy-ribose (FDR), affording the desired candidate PET tracers, e.g., II in variable yields. The same ligation reactions performed on L-ribose – a byproduct of [18F]FDR radiosynthesis – under conditions mimicking a radiochem. production and showed that the fluorinated adducts can be efficiently purified and isolated by HPLC. Finally, one of the prospective hypoxia tracers was successfully produced in radiolabeled form in 29.2% radiochem. yield from [18F]FDR. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Electric Literature of C5H5N3O4).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C5H5N3O4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New bi-functional zinc catalysts based on robust and easy-to-handle N-chelating ligands for the synthesis of cyclic carbonates from epoxides and CO₂ under mild conditions was written by Luo, Rongchang;Zhou, Xiantai;Zhang, Wuying;Liang, Zhongxiu;Jiang, Jun;Ji, Hongbing. And the article was included in Green Chemistry in 2014.Reference of 21252-69-7 This article mentions the following:

Novel zinc complexes were prepared by covalent linkage of various imidazolium-based ionic liquid moieties with the 2,2′-bipyridine ligand on the two sides of the 4,4′-position. The zinc(II) complexes containing the rigid N-chelating ligand proved to be stable, highly efficient and easy-to-handle catalysts towards the synthesis of cyclic carbonate from epoxide and CO₂ without the use of any co-catalyst or organic solvent. The catalysts can be easily recovered and reused without significant loss of activity and selectivity by control of the solvent. The kinetic study uncovered that the reaction was 1st-order with respect to the epoxide. Also, a plausible reaction mechanism was proposed, in which the zinc center could promote ring-opening of the epoxide for the synergetic effect with the anion X^– in ILs. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cornstalk liquefaction in methanol/water mixed solvents was written by Zhu, Wei-Wei;Zong, Zhi-Min;Yan, Hong-Lei;Zhao, Yun-Peng;Lu, Yao;Wei, Xian-Yong;Zhang, Dongke. And the article was included in Fuel Processing Technology in 2014.Computed Properties of C4H5N3O2 This article mentions the following:

Cornstalk liquefaction (CSL) in methanol, water or methanol/water mixed solvents was studied at 250-320 °C. Each reaction mixture was separated into extract 1 (E₁, including the solute in filtrate and methanol-extractable portion), extract 2 (E₂, methanol-inextractable but isometric carbon disulfide/acetone-extractable portion) and residue (isometric carbon disulfide/acetone-inextractable portion) by filtration and sequential extraction with methanol and isometric carbon disulfide/acetone mixed solvent. The cornstalk, E₁, E₂ and the residues were analyzed using a Fourier transformation IR spectrometer and each E₁ was analyzed using a gas chromatog./mass spectrometer. The microstructures of the cornstalk and its derived residues were observed with a scanning electron microscope. The results show that methanol and water exhibited a synergic effect on the CSL. The isometric methanol and water mixed solvent was found to be most effective for CSL at 300 °C for 30 min. Under such conditions, the total yield of gases, E₁ and E₂ and the yield of E₁ reached 88.1% and 52.4%, resp. The yields decreased as the temperature or time was further increased, suggesting that some of the extractable species were repolymd. at higher temperatures or for prolonged time. E₁ consisted of hydrocarbons, alkanols, tetrahydrofuranylmethanols, arenols, methoxyalkanes, methoxyarenes, ketones, carboxylic acids, esters, chloromethylbenzenes, nitrogen-containing species and several other species. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Computed Properties of C4H5N3O2).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Computed Properties of C4H5N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Deubiquitinase-targeting chimeras for targeted protein stabilization was written by Henning, Nathaniel J.;Boike, Lydia;Spradlin, Jessica N.;Ward, Carl C.;Liu, Gang;Zhang, Erika;Belcher, Bridget P.;Brittain, Scott M.;Hesse, Matthew J.;Dovala, Dustin;McGregor, Lynn M.;Valdez Misiolek, Rachel;Plasschaert, Lindsey W.;Rowlands, David J.;Wang, Feng;Frank, Andreas O.;Fuller, Daniel;Estes, Abigail R.;Randal, Katelyn L.;Panidapu, Anoohya;McKenna, Jeffrey M.;Tallarico, John A.;Schirle, Markus;Nomura, Daniel K.. And the article was included in Nature Chemical Biology in 2022.Category: imidazoles-derivatives This article mentions the following:

Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we present deubiquitinase-targeting chimeras (DUBTACs), heterobifunctional small mols. consisting of a deubiquitinase recruiter linked to a protein-targeting ligand, to stabilize the levels of specific proteins degraded in a ubiquitin-dependent manner. Using chemoproteomic approaches, we discovered the covalent ligand EN523 that targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1. We showed that a DUBTAC consisting of our EN523 OTUB1 recruiter linked to lumacaftor, a drug used to treat cystic fibrosis that binds ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR), robustly stabilized ΔF508-CFTR protein levels, leading to improved chloride channel conductance in human cystic fibrosis bronchial epithelial cells. We also demonstrated stabilization of the tumor suppressor kinase WEE1 in hepatoma cells. Our study showcases covalent chemoproteomic approaches to develop new induced proximity-based therapeutic modalities and introduces the DUBTAC platform for TPS. [graphic not available: see fulltext] In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methylimidazole (cas: 25676-75-9Category: imidazoles-derivatives).

4-Bromo-1-methylimidazole (cas: 25676-75-9) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem