Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives was written by Bellina, Fabio;Biagetti, Matteo;Guariento, Sara;Lessi, Marco;Fausti, Mattia;Ronchi, Paolo;Rosadoni, Elisabetta. And the article was included in RSC Advances in 2021.COA of Formula: C8H8N2 This article mentions the following:
A variety of 2-alkynyl(benzo)imidazoles I (R = Ph, n-hexyl, 2-chlorophenyl, etc.; R1 = R2 = H; R1R2 = -CH=CH-CH=CH-) have been synthesized by dehydrogenative alkynation of N-methylimidazole or 1-methyl-1H-1,3-benzodiazole with terminal alkynes RCCH in NMP under air in the presence of Ag2CO3 as the oxidant and Pd(OAc)2 as the catalyst precursor. The data obtained in this study support a reaction mechanism involving a non-concerted metalation deprotonation (n-CMD) pathway. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3COA of Formula: C8H8N2).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C8H8N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem