Selective reductions of 1-(carbonyl)substituted 2-nitroimidazoles with alkali metal borohydrides and with borane-tetrahydrofuran was written by Threadgill, Michael D.;Webb, Paul. And the article was included in Synthetic Communications in 1990.Application In Synthesis of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid This article mentions the following:
NaBH4, LiBH4, and BH3.THF reduce carbonyl groups (esters, amide) in 1-substituted 2-nitroimidazoles I ( R = CO2Me, CONH2) in high yield without reduction of the nitroheterocycle to give I ( R = CH2OH, CH2NH2) resp. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Application In Synthesis of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid).
2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 2-(2-Nitro-1H-imidazol-1-yl)acetic acid
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem