An alternative approach to the synthesis of lexitropsins was written by Ryabinin, V. A.;Sinyakov, A. N.. And the article was included in Bioorganicheskaya Khimiya in 1998.Quality Control of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate This article mentions the following:
An alternative approach to the synthesis of lexitropsins, e.g. I (Tr = CPh3, n = 1 – 4), based on the elongation of an oligocarboxamide chain from the N-terminus of a mol. is discussed. This method was applied to the preparation of lexitropsins containing 1-methylpyrrole-2-carboxamide, 1-methylimidazole-2-carboxamide, and 1,3-thiazole-4-carboxamide monomer units. In the experiment, the researchers used many compounds, for example, Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9Quality Control of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate).
Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate (cas: 109012-23-9) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Quality Control of Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem