High-throughput photocapture approach for reaction discovery was written by Bayly, Alison A.;McDonald, Benjamin R.;Mrksich, Milan;Scheidt, Karl A.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2020.Electric Literature of C8H8N2 This article mentions the following:
Modern organic reaction discovery and development relies on the rapid assessment of large arrays of hypothesis-driven experiments The time-intensive nature of reaction anal. presents the greatest practical barrier for the execution of this iterative process that underpins the development of new bioactive agents. Toward addressing this critical bottleneck, the authors report herein a high-throughput anal. (HTA) method of reaction mixtures by photocapture on a 384-spot diazirine-terminated self-assembled monolayer, and self-assembled monolayers for matrix-assisted laser desorption/ionization mass spectrometry (SAMDI-MS) anal. This anal. platform has been applied to the identification of a single-electron-promoted reductive coupling of acyl azolium species. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Electric Literature of C8H8N2).
1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C8H8N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem