Unusual synthesis of stable pyridinium dinitromethylides was written by Andreasson, Eva;Newton, Christopher G.;Ollis, W. David;Rees, Charles W.;Smith, David I.;Wright, Derek E.. And the article was included in Journal of the Chemical Society, Chemical Communications in 1983.Formula: C9H8N2O2 This article mentions the following:
Nitration of imidazo[1,2-a]pyridines with concentrated HNO3 and H2SO4 at room temperature gave pyridinium dinitromethylides in 51-85% yield; these compounds have orthogonal pyridinium and dinitromethylide groups. E.g., treatment of ester I with fuming HNO3-concentrated H2SO4 at room temperature gave 61% ylide II. Reaction mechanisms involving sequential nitration and ring cleavage are discussed. In the experiment, the researchers used many compounds, for example, Methyl imidazo[1,2-a]pyridine-5-carboxylate (cas: 88047-55-6Formula: C9H8N2O2).
Methyl imidazo[1,2-a]pyridine-5-carboxylate (cas: 88047-55-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Formula: C9H8N2O2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem