Oxidation of methylbenzimidazoles with ceric ammonium nitrate was written by Talaty, C. N.;Zenker, N.;Callery, P. S.. And the article was included in Journal of Heterocyclic Chemistry in 1976.HPLC of Formula: 58442-17-4 This article mentions the following:
The benzimidazolecarboxaldehydes I (R = R1 = R3 = H, R2 = CHO; R = Me, R1 = R3 = H, R2 = CHO; R = R1 = H, R2 = CHO, R3 = Me; R = R3 = Me, R1 = H, R2 = CHO) were prepared in 25-60% yields by treating I (R = R1 = R3 = H, R2 = Me; R = R2 = Me, R1 = R3 = H; R = R1 = H, R2 = R3 = Me; R = R2 = R3 = Me, R1 = H, resp.) with ceric ammonium nitrate in H2SO4. In the experiment, the researchers used many compounds, for example, 1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4HPLC of Formula: 58442-17-4).
1H-Benzimidazole-5-carbaldehyde (cas: 58442-17-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.HPLC of Formula: 58442-17-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem