Study of memory-enhancing effects of substituted amides of imidazole-4(5)-carboxylic acid in rats was written by Shabanov, P. D.;Piotrovskii, L. B.;Dumpis, M.. And the article was included in Farmakologiya i Toksikologiya (Moscow) in 1988.Reference of 26832-08-6 This article mentions the following:
The effects of four derivatives of imidazole-4(5)-carboxylic acid (I; R = H, Me; R1 = H, Me, β-phenylisopropyl) on the formation and extinction of a conditioned drinking reflex and preservation of a conditioned response of passive avoidance after electroconvulsive shock or craniocerebral injury were studied in experiments on rats. The N-methylamide of imidazole-4(5)-carboxylic acid exhibited the greatest psychostimulating and antiamnesia activity. Addition of the β-phenylisopropyl radical to the amino group resulted in the appearance of depressant properties. In the experiment, the researchers used many compounds, for example, 1H-Imidazole-4-carboxamide (cas: 26832-08-6Reference of 26832-08-6).
1H-Imidazole-4-carboxamide (cas: 26832-08-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 26832-08-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem