Enantioselective Hydrogenation of Imidazo[1,2-a]pyridines was written by Schlepphorst, Christoph;Wiesenfeldt, Mario P.;Glorius, Frank. And the article was included in Chemistry – A European Journal in 2018.Reference of 69214-09-1 This article mentions the following:
The enantioselective synthesis of tetrahydroimidazo[1,2-a]pyridines by direct hydrogenation was achieved using a ruthenium/N-heterocyclic carbene (NHC) catalyst. The reaction forgoes the need for protecting or activating groups, proceeds with complete regioselectivity, good to excellent yields, enantiomeric ratios of up to 98:2, and tolerates a broad range of functional groups [e.g., I → II (95.5:4.5 e.r., 99% isolated yield)]. 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridines, which are found in numerous bioactive mols., were directly obtained by this method, and its applicability was demonstrated by the (formal) synthesis of several functional mols. In the experiment, the researchers used many compounds, for example, 5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1Reference of 69214-09-1).
5-Bromoimidazo[1,2-a]pyridine (cas: 69214-09-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 69214-09-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem