Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine was written by Mukherjee, Arijit;Rogers, Robin D.;Myerson, A. S.. And the article was included in CrystEngComm in 2018.Product Details of 404001-48-5 This article mentions the following:
Liquid assisted grinding using imidazolium-based ionic liquids (IL-AG) was found to be effective in isolation of cocrystals and cocrystal polymorphs. Isolation of specific polymorphs of caffeine-citric acid (CAF-CA) and caffeine-glutaric acid (CAF-GLU) cocrystals highlights the tunability of ILs in polymorphic control. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Product Details of 404001-48-5).
3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 404001-48-5
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem