DNA-Based Asymmetric Inverse Electron-Demand Hetero-Diels-Alder was written by Mansot, Justine;Lauberteaux, Jimmy;Lebrun, Aurelien;Mauduit, Marc;Vasseur, Jean-Jacques;Marcia de Figueiredo, Renata;Arseniyadis, Stellios;Campagne, Jean-Marc;Smietana, Michael. And the article was included in Chemistry – A European Journal in 2020.Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone This article mentions the following:
While artificial cyclases hold great promise in chem. synthesis, this work presents the first example of a DNA-catalyzed inverse electron-demand hetero-Diels-Alder (IEDHDA) between dihydrofuran and various α,β-unsaturated acyl imidazoles. The resulting fused bicyclic O,O-acetals containing three contiguous stereogenic centers I (R = Me, c-hexyl, Ph, etc.) are obtained in high yields (up to 99%) and excellent diastereo- (up to >99:1 dr) and enantioselectivities (up to 95% ee) using a low catalyst loading. Most importantly, these results show that the concept of DNA-based asym. catalysis can be expanded to new synthetic transformations offering an efficient, sustainable, and highly selective tool for the construction of chiral building blocks. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of 1-(1-Methyl-1H-imidazol-2-yl)ethanone
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem