Li, Shixiong et al. published their research in Polyhedron in 2019 | CAS: 3012-80-4

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 3012-80-4

Terminal anion induced zinc(II) mononuclear complexes trans-to-cis isomerization regulate photoluminescence properties and its solution behavior was written by Li, Shixiong;Liu, Lingmei;Deng, Yan;Huang, Yuanhao;Chen, YuFeng;Liao, Beiling. And the article was included in Polyhedron in 2019.Reference of 3012-80-4 This article mentions the following:

The organic ligand 1-methyl-1H-benzo[d]imidazole-2-carbaldehyde (L’) was used to react with ZnX2 (X = Cl and Br) under solvothermal conditions to obtain [Zn(L)2(X)2] (1, X = Cl; 2, X = Br). The ligand of L’ transforms into 1-methyl-1H-benzo[d]imidazole (L). The structures anal. shows that the L’ ligands of complex 1 and 2 coordinate in different way, which results different shapes in every structure. They are trans and cis isomers of Zn(II) mononuclear complexes induced by terminal anions. These also lead to the difference of weak interaction of complexes, thus affecting the mode of connection. Also, the electrospray ionization mass spectrometry (ESI-MS) data show that the main mol. fragment was [Zn(L)2(X)]+ under the condition of 0 eV voltage. So those two complexes were relatively stable in CH3CN. The single crystals of complex 1 showed blue green light, but complex 2 showed very obvious blue and white light under UV lamp, this difference may be due to the ion radius of coordination halogen. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Reference of 3012-80-4).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 3012-80-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem