Synthesis of [18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)acetamide], a marker for PET detection of hypoxia was written by Josse, Olivier;Labar, Daniel;Georges, Benoit;Gregoire, Vincent;Marchand-Brynaert, Jacqueline. And the article was included in Bioorganic & Medicinal Chemistry in 2001.Application of 22813-32-7 This article mentions the following:
[18F]-2-(2-Nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)acetamide ([18F]-EF3) has been prepared in 65% chem. yield and 5% radiochem. yield by coupling 2,3,5,6-tetrafluorophenyl 2-(2-nitroimidazol-1-yl)acetate with [18F]-3,3,3-trifluoropropylamine. This original radiolabeled key synthon was obtained in 40% overall chem. yield by oxidative [18F]-fluorodesulfurization of Et N-phthalimido-3-aminopropanedithioate, followed by deprotection with hydrazine of the resulting [18F]-N-phthalimido-3,3,3-trifluoropropylamine. The process was performed within 90 min, from the [18F]-HF production in the cyclotron to the purification of the final target. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Application of 22813-32-7).
2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 22813-32-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem