Potential radiosensitizing agents. 5. 2-Substituted benzimidazole derivatives was written by Gupta, Rajender P.;Larroquette, Cynthia A.;Agrawal, Krishna C.. And the article was included in Journal of Medicinal Chemistry in 1982.Formula: C9H9N3 This article mentions the following:
Benzimidazoles I [R = CH2CH(OH)CH2OMe, CH2CO2Et; R1 = CONH2, Ac, CF3, CN, SO2Me, NO2; R2, R3 = H, NO2] were prepared, e.g., by alkylation of I (R = H) with 1,2-epoxy-3-methoxypropane in the presence of K2CO3. Reaction of I (R1 = NO2, SO2Me) with the epoxide also yielded a benzimidazo[2,1-b]oxazole derivative I (R1 = NO2) showed the highest radiosensitizing activity against Chinese hamster cells (V-79) in culture. In the experiment, the researchers used many compounds, for example, 2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7Formula: C9H9N3).
2,3-Dihydro-1H-benzo[d]imidazo[1,2-a]imidazole (cas: 24134-26-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Formula: C9H9N3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem