Model reactions for enzymic catalysis. IV. Structure-activity relationship of new transaminators with imidazole, thiazole, and benzimidazole skeletons was written by Gerbert, Ulrich;Von Kerekjarto, Bela. And the article was included in Justus Liebigs Annalen der Chemie in 1974.Synthetic Route of C9H8N2O This article mentions the following:
The substituents in position 1 of 2-formylimidazoles (I, R = e.g. H, CH2Ph, Me, or CHMe2) affected the initial velocities but not the equilibrium of transamination of alanine. Similar results were obtained in transamination of alanine-2-oxoglutarate with the trans-aminators I. The reaction mechanism recently postulated by the authors (1969) was confirmed by the finding that some isoelectronic structural analogs of thiazole and benzimidazole were also active transaminators. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Synthetic Route of C9H8N2O).
1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Synthetic Route of C9H8N2O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem