Inhibition of dealkylation of 7-methoxy and 7-ethoxycoumarin in rat liver microsomes by disulfiram, 2-n-octyl benzimidazole, chloramphenicol and propranolol was written by Fry, Jeffrey R.. And the article was included in IRCS Medical Science in 1984.Electric Literature of C15H22N2 This article mentions the following:
Both the 7-methoxy- [72750-64-2] and 7-ethoxycoumarin dealkylase [42613-26-3] activities of rat liver microsomes were equally inhibited by cytochrome P 450 [9035-51-2] antagonists with the following order of potency: disulfiram [97-77-8] > 2-n-octyl benzimidazole [13060-24-7] > chloramphenicol [56-75-7] > propranolol [525-66-6]. Thus, whereas all 4 compounds are effective inhibitors of cytochrome P 450-dependent monooxygenase [9038-14-6] activity, they do not show any selectivity for the constitutive forms of cytochrome P 450 involved in the dealkylation of the 7-alkoxycoumarins. In the experiment, the researchers used many compounds, for example, 2-Octylbenzimidazole (cas: 13060-24-7Electric Literature of C15H22N2).
2-Octylbenzimidazole (cas: 13060-24-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C15H22N2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem