Formulation and evaluation of candesartan co-precipitate with hydrophilic polymers; preparation of orodispersible tablets was written by Deweda, Asmaa M.;Essa, Ebtessam A.;Donia, Ahmed A.. And the article was included in European Journal of Biomedical and Pharmaceutical Sciences in 2019.Application of 145040-37-5 This article mentions the following:
Candesartan cilexetil is an angiotensin-receptor blocker that suffer from inadequit and variable oral bioavailability due to its poor aqueous solubility and presystemic metabolism Therefore, the objectives of this study was to enhance candesartan cilexetil dissolution with subsequent preparation of mouth dispersable tablets. The drug was precipitated from its ethanolic solution over Aerosil 200 as carrier for the deposited microcrystals. To improve surface wettability, the precipitation step was performed in presence of hydrophilic polymer. The selected polymers were polyvinylpyrrolidone 40T (PVP), hydroxypropylmethyl cellulose E5 (HPMC), Poloxamer 407 and polyethylene glycol6000 (PEG). The products were evaluated regarding dissolution pattern. Phys. characterization was also evaluated for selected formulations. Thermal behavior and X-ray powder diffraction results confirmed reduced drug crystalinity. Infra-red spectroscopy indicated drug-excipient compatibilty. All formulations showed imrovement in drug dissolution compared to pure drug. Presence of polymer resulted in higher initial release and dissolution efficiency. Best formulations regarding dissolution were successifly used in the preparation of oral dispersible tablets with fast drug release. Drug precipitation over carrier with large surface area in presence of hydrophilic polymer is a promising approach for enhancing dissolution rate of poorly soluble drugs. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Application of 145040-37-5).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application of 145040-37-5
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem