Asymmetric α-Functionalization of 2-Alkyl Azaarenes: Synthesis of Tertiary Fluorides Having Vicinal Stereogenic Centers was written by Das, Arko;Joshi, Harshit;Singh, Vinod K.. And the article was included in Organic Letters in 2021.Electric Literature of C6H8N2O This article mentions the following:
An enantioselective approach for synthesizing fluorinated azaarenes containing vicinal quaternary-tertiary stereocenters I [R1 = Ph, CH=CHPh, 2-thienyl, etc.; R2 = Me, OMe, OEt, Ph; R3 = 2-pyridyl, benzo[d]thiazol-2-yl] was summarized. The chiral copper(I)-phosphine complex binded with the azaarenes followed by Michael addition to unsaturated acyl imidazoles, resulting in α-functionalized products with an excellent level of enantioselectivities (up to 99%), diastereoselectivities (>20:1), and yields (up to 97%). Furthermore, post-functionalization of the acyl imidazole part had also been demonstrated. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Electric Literature of C6H8N2O).
1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C6H8N2O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem