Exploitation of localized surface plasmon resonance of silver/gold nanoparticles for the fluorescence quantification of angiotensin II receptor antagonists in their tablets and bio-samples was written by Alarfaj, N. A.;Altamimi, S. A.;El-Tohamy, M. F.;Almahri, A. M.. And the article was included in New Journal of Chemistry in 2019.Product Details of 145040-37-5 This article mentions the following:
The present study suggested six different fluorometric systems for the determination of three angiotensin II receptor antagonists, candesartan cilexetil (CDC), valsartan (VAL) and telmisartan (TEL) in their bulk and pharmaceutical dosage forms. The fluorescence intensities (FIs) were recorded by measuring the high catalytic potential activity of silver or gold nanoparticles (AgNPs or AuNPs) at λex 525, 420 and 330 nm and λem 555, 490 and 400 nm for CDC, VAL and TEL, resp. All exptl. measurements were carried out under optimum conditions using the CDC-Tb(III)-AgNPs, CDC-Tb(III)-AuNPs, VAL-Eu(III)-AgNPs, VAL-Eu(III)-AuNPs, TEL-SDS-AgNPs and TEL-SDS-AuNPs systems. The fluorescence (FL) signals displayed linear concentration ranges of 0.01-300, 0.02-120 and 2.0-30 ng mL-1 for CDC, VAL and TEL in the presence of AgNPs, resp., and 0.05-60, 0.1-80 and 0.1-250 ng mL-1 for the same drugs in the presence of AuNPs, resp. The influence of possible coexisting species and additives was tested. ICH guidelines were followed to validate the developed methods. All suggested FL systems were successfully used to monitor the studied drugs in bulk, tablets and bio-samples. The obtained data were compared with those of other reported methods revealing high agreement. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Product Details of 145040-37-5).
1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Product Details of 145040-37-5
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem