Month: January 2023

Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives was written by Bellina, Fabio;Biagetti, Matteo;Guariento, Sara;Lessi, Marco;Fausti, Mattia;Ronchi, Paolo;Rosadoni, Elisabetta. And the article was included in RSC Advances in 2021.COA of Formula: C8H8N2 This article mentions the following:

A variety of 2-alkynyl(benzo)imidazoles I (R = Ph, n-hexyl, 2-chlorophenyl, etc.; R¹ = R² = H; R¹R² = -CH=CH-CH=CH-) have been synthesized by dehydrogenative alkynation of N-methylimidazole or 1-methyl-1H-1,3-benzodiazole with terminal alkynes RCCH in NMP under air in the presence of Ag₂CO₃ as the oxidant and Pd(OAc)₂ as the catalyst precursor. The data obtained in this study support a reaction mechanism involving a non-concerted metalation deprotonation (n-CMD) pathway. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3COA of Formula: C8H8N2).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electrospun nylon 6 nanofibers incorporated with 2-substituted N-alkylimidazoles and their silver(I) complexes for antibacterial applications was written by Kleyi, Phumelele;Frost, Carminita L.;Tshentu, Zenixole R.;Torto, Nelson. And the article was included in Journal of Applied Polymer Science in 2014.Application of 21252-69-7 This article mentions the following:

The article presents the incorporation of biocides [2-substituted N-alkylimidazoles and their silver(I) complexes] into electrospun nylon 6 nanofibers for application as antimicrobial materials. The electrospun nylon 6/biocides nanofiber composites were characterized by IR spectroscopy (ATR-FTIR) and SEM (SEM-EDX). The antimicrobial activity of the electrospun nylon 6/biocides nanofiber composites was evaluated against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis subsp. spizizenii using the disk diffusion method, the American Association for Textile Chemists and Colorists test method 100-2004 and the dynamic shake flask method (American Society for Testing and Materials E2149-10). The electrospun nylon 6 nanofibers incorporated with 2-substituted N-alkylimidazoles displayed moderate to excellent levels of growth reduction against S. aureus (73.2-99.8%). For the electrospun nylon 6 nanofibers incorporated with silver(I) complexes, the levels of growth reduction were >99.99%, for both E. coli and S. aureus, after the antimicrobial activity evaluation using the shake flask method. The study demonstrated that the electrospun nanofibers, fabricated using the incorporation strategy, have the potential to be used as attractive antimicrobial materials. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electrophilic properties of nitroheterocyclic compounds. was written by Zieba-Mizgala, Anna;Puszko, Aniela;Regiec, Andrzej;Kuduk-Jaworska, Janina. And the article was included in Bioelectrochemistry in 2005.Reference of 3034-41-1 This article mentions the following:

Investigation of the reduction potential and calculation of the partition coefficient n-octanol/water allow the assessment of the potential suitability of nitropyridine N-oxide compounds in radiotherapy of cancer. Experiments were carried out using cyclic voltammetry with HMDE as working electrode. The electrode reduction of the investigated compounds is quite irreversible and strongly dependent on pH. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Reference of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Interaction of Ionic Liquids with a Lipid Bilayer: A Biophysical Study of Ionic Liquid Cytotoxicity was written by Jing, Benxin;Lan, Nan;Qiu, Jie;Zhu, Yingxi. And the article was included in Journal of Physical Chemistry B in 2016.Related Products of 404001-48-5 This article mentions the following:

Ionic liquids (ILs) have been widely considered and used as “green solvents” for more than two decades. However, their ecotoxicity results have contradicted this view, as ILs, particularly hydrophobic ones, are reported to exhibit high toxicity. Yet the origin of their toxicol. remains unclear. In this work, we have investigated the interaction of amphiphilic ILs with a lipid bilayer as a model cell membrane to understand their cytotoxicity at a mol. level. By employing fluorescence imaging and light and X-ray scattering techniques, we have found that amphiphilic ILs could disrupt the lipid bilayer by IL insertion, end-capping the hydrophobic edge of the lipid bilayer, and eventually disintegrating the lipid bilayer at high IL concentration The insertion of ILs to cause the swelling of the lipid bilayer shows strong dependence on the hydrophobicity of IL cationic alky chain and anions and is strongly correlated with the reported IL cytotoxicity. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Related Products of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Related Products of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalytic Behavior of Au Confined in Ionic Liquid Film: A Kinetics Study for the Hydrochlorination of Acetylene was written by Wang, Bolin;Zhang, Haifeng;Yue, Yuxue;Li, Changlin;Zhao, Jia. And the article was included in Catalysts in 2022.Recommanded Product: 79917-89-8 This article mentions the following:

A systematic study of the kinetics of supported-ionic-liquid-phase (SILP) Au catalysis (Au-IL/AC) has been established in the continuous gas-phase hydrochlorination of acetylene. We reveal that the effect of ionic liquid (IL) film on substrate diffusion can be eliminated. The reaction order of the catalyst indicates that Au is confirmed to exist as a monomer in the IL film of the Au-IL/AC system, which is different from the fast equilibrium of the “Au dimer and monomer” for the classical Au/AC catalyst. The homogeneous reaction micro-environment is confirmed for Au-IL/AC since the activation energy was little changed under both heterogeneous and homogeneous catalysis, further verifying the monat. characteristics of Au in Au-IL/AC. Due to the supported IL film, the reaction order of hydrogen chloride was decreased from 1 to 0.5 while creating a hydrogen chloride enrichment system around Au, which provides the possibility of producing vinyl chloride with an equal substrates feed ratio. This kinetic-perspective-based revelation of the catalytic behavior of the metal active sites confined in IL film enriches and expands the SILP catalytic system for acetylene hydrochlorination. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Recommanded Product: 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Responsive Ionogel Surface with Renewable Antibiofouling Properties was written by Ye, Lijun;Chen, Fei;Liu, Jie;Gao, Aiting;Kircher, Gunnar;Liu, Wendong;Kappl, Michael;Wegner, Seraphine;Butt, Hans-Juergen;Steffen, Werner. And the article was included in Macromolecular Rapid Communications in 2019.Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide This article mentions the following:

The synthesis of ionogels with a responsive, self-replenishing surface for combating biofouling is described. Ionogels are prepared by infiltrating poly(vinylidene fluoride-co-hexafluoropropylene) with binary mixtures of ionic liquids (IL): 1-octadecyl-3-methylimidazolium bis(trifluoromethyl sulfonyl)imide ([C₁₈C₁i.m.][NTf₂], m.p. T_m = 55 °C) and 1-hexyl-3-methylimidazolium bis(trifluoromethyl sulfonyl)imide ([C₆C₁i.m.][NTf₂], T_m = -9 °C). The IL mixtures release spontaneously from the gel matrix and eventually crystallize on the surface. This leads to self-replenishment of the surface of ionogels even after mech. damage. The incorporation of [C₆C₁i.m.][NTf₂] provides the antimicrobial efficacy of ionogels while the crystals of [C₁₈C₁i.m.][NTf₂] serve as a skeleton maintaining [C₆C₁i.m.][NTf₂] on the surface. By heating, the ionogel surface transforms from solid to liquid-infused state-the removal of biofilms/bacteria developed under a long time of colonization is facilitated. The antimicrobial efficacy is maintained even after several cycles of biofilm formation and detachment. This work provides an opportunity to apply ionogels as functional coatings with renewable antibiofouling properties. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New ionic organic compounds containing a linear tris(imidazolium) core and their thermotropic liquid crystal behavior was written by Schenkel, Magdalene R.;Shao, Renfan;Robertson, Lily A.;Wiesenauer, Brian R.;Clark, Noel A.;Gin, Douglas L.. And the article was included in Liquid Crystals in 2013.Computed Properties of C11H20N2 This article mentions the following:

Imidazolium-containing thermotropic ionic liquid crystals (TILCs) are of interest because of their structural similarity to imidazolium-based ionic liquids (ILs), allowing them to exhibit some IL-like properties in addition to the LC order. More imidazolium units are important for increasing the IL character; however, the effect of multiple imidazolium units on LC behavior is not well known. Most reported imidazolium TILCs contain one imidazolium unit; only a handful containing multiple imidazolium units is known. The only examples of TILCs with multiple imidazolium units sequentially linked with a flexible spacer are based on an alkyl- or oligo(ethylene oxide)-bridged bis(imidazolium) core with an n-alkyl tail at each end. Herein, a series of ten new sym. compounds containing three hexyl-bridged imidazolium bromide units as the core and two terminal alkyl chains was synthesized and analyzed. Thermotropic LC phases were generally not observed for homologs with even-numbered tails less than 16 carbons. However, after initial annealing, the homologs containing 16-carbon, 18-carbon and 20-carbon tails, all form a smectic A phase in the 25-137° range, with the latter two also forming a higher-order smectic phase. This indicates that with sufficiently long alkyl tails to counterbalance the poly(ion) core, these tris(imidazolium) salts can exhibit thermotropic mesomorphism. The title compounds thus formed included a tris[imidazolium] tribromide compound (I) [1,3-bis[6-(1-alkyl-1H-imidazolium-3-yl)hexyl]imidazolium tribromide] and related substances. The synthesis of the target compounds was achieved by a reaction of 1,3-bis(6-bromohexyl)-1H-imidazolium bromide with alkyl bromides. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Computed Properties of C11H20N2).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Computed Properties of C11H20N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ligand-Promoted Rh^I-Catalyzed C2-Selective C-H Alkenylation and Polyenylation of Imidazoles with Alkenyl Carboxylic Acids was written by Zhao, Haoqiang;Luo, Zhenli;Yang, Ji;Li, Bohan;Han, Jiahong;Xu, Lijin;Lai, Wenzhen;Walsh, Patrick J.. And the article was included in Chemistry – A European Journal in 2022.Product Details of 83741-35-9 This article mentions the following:

The first RhI-catalyzed, directed decarbonylative C2-H alkenylation of imidazoles with readily available alkenyl carboxylic acids is reported. The reaction proceeds in a highly regio- and stereoselective manner, providing efficient access to C2-alkenylated imidazoles that are generally inaccessible by known C-H alkenylation methods. This transformation accommodates a wide range of alkenyl carboxylic acids, including challenging conjugated polyene carboxylic acids, and diversely decorated imidazoles with high functional group compatibility. The presence of a removable pyrimidine directing group and the use of a bidentate phosphine ligand are pivotal to the success of the catalytic reaction. This process is also suitable for benzimidazoles. Importantly, the scalability and diversification of the products highlight the potential of this protocol in practical applications. Detailed exptl. and computational studies provide important insights into the underlying reaction mechanism. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-benzoimidazole (cas: 83741-35-9Product Details of 83741-35-9).

4-Bromo-1H-benzoimidazole (cas: 83741-35-9) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Product Details of 83741-35-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A New Model for Prediction of One Electron Reduction Potential of Nitroaryl Compounds was written by Fareghi-Alamdari, Reza;Zandi, Farzad;Keshavarz, Mohammad Hossein. And the article was included in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2015.COA of Formula: C5H5N3O4 This article mentions the following:

This paper introduces a simple model for prediction of one electron reduction potential [E(RNO₂/R^•NO₂^–)] of various nitroaryl compounds The new method uses energy difference between HOMO (HOMO) and LUMO (LUMO) in gas phase at the B3LYP/6-311++G** level (ΔE_HOMO-LUMO) and some structural parameters. It was used for 35 nitroaryl compounds including nitrobenzenes, nitrofurans, 2-nitroimidazoles, 4-nitroimidazoles, 5-ninuintidazoles, nitroazaindoles, nitroacridines, and miscellaneous nitroaryl compounds The root mean square (rms) percent deviation and the average absolute error of predictions of E(RNO₂/R^•NO₂^–) relative to experiment were decreased from 12.4 % and 0.42 V to 3.5 % and 0.11 V, resp., upon consideration of several structural parameters. Increment of the value of ΔE_HOMO-LUMO and inclusion of specific polar groups can increase thermodn. stability of these compounds In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7COA of Formula: C5H5N3O4).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C5H5N3O4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem