Month: December 2022

Subramanian, Saravanan published the artcileSustainable Nanoporous Benzoxazole Networks as Metal-Free Catalysts for One-Pot Oxidative Self-Coupling of Amines by Air Oxygen, Application of 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Advanced Sustainable Systems (2017), 1(10), 1-7, database is CAplus.

Here, an efficient, nanoporous, heterogeneous benzoxazole catalyst is reported for aerobic oxidative coupling of amines. A mol. design strategy is presented to functionalize primary amines to produce valuable products under one-pot, open-air reaction conditions. Unprecedented and previously unknown, the stable imine intermediate catalyzes its own formation, also known as autocatalysis, enabling a direct and favorable access to amino acids, even if the catalysts are absent. The biomimetic benzoxazole catalysts developed here provide quant. catalytic activity over 50 cycles with favorable kinetics with no degradation This work also marks the first use of benzoxazoles for oxidative catalytic reactions.

Advanced Sustainable Systems published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C17H37NO3, Application of 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Delgado, F. published the artcileNonpeptide angiotensin II receptor antagonists: synthesis and biological activity of 1H-imidazo and 1H-[1,2,3]-triazolo fused derivatives, Safety of (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, the publication is Farmaco (1997), 52(3), 147-155, database is CAplus and MEDLINE.

Title compounds such as I [A = CH, CBu, N; R = H or RR = (CH:CH)₂; B = CH:CH, S; G = COOH, CN, 1H-tetrazol-5-yl] were prepared as angiotensin II receptor antagonists. Modification of the classical biphenyl moiety to a 4-arylthienyl fragment afforded interesting activities.

Farmaco published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Safety of (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sung, Daekyung published the artcileFacile Method for Selective Immobilization of Biomolecules on Plastic Surfaces, HPLC of Formula: 359860-27-8, the publication is Langmuir (2009), 25(19), 11289-11294, database is CAplus and MEDLINE.

A key aspect of biochip and biosensor preparation is optimizing surface attachment of biomols. Here, the authors report a facile approach for selectively immobilizing biomols. on amphiphilic polymer-coated plastic surfaces with anti-biofouling properties. To modify plastic surfaces, the authors synthesized two types of random copolymers by radical polymerization, which consisted of three parts: an anchoring group; a PEG component, which acted as a repellent of nonspecific biomols.; and a functional group, to which biomols. were conjugated. Dodecyl- and benzyl-based copolymers were highly soluble in water, presumably due to the presence of multiple PEG groups, and could easily coat the model plastic surface (polystyrene) in an aqueous environment. The antibiofouling property of each polymer-coated plastic surface was examined by measuring the extent of nonspecific protein adsorption using bovine serum albumin (BSA). Both polymer-coated plastic surfaces showed a very low level of BSA adsorption relative to that of an uncoated plastic surface (control). Finally, the authors showed that streptavidin and antibodies, as representative biomols., could be selectively immobilized on the polymer-coated plastic surfaces imprinted with biotin and protein A, resp., by microcontact printing, exhibiting an intense signal with low background.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C9H11BO4, HPLC of Formula: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Park, Tae Jung published the artcileAlignment of SWNTs by protein-ligand interaction of functionalized magnetic particles under low magnetic fields, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Journal of Nanoscience and Nanotechnology (2011), 11(5), 4540-4545, database is CAplus and MEDLINE.

A simple method to controllably align single-walled CNTs (SWNTs) by magnetic particles embedded with superparamagnetic iron oxide as an accelerator under the magnetic field was developed. The functionalization of SWNTs using biotin, interacted with streptavidin-coupled magnetic particles (micro-to-nano in diameter), and layer-by-layer assembly were performed for the alignment of a particular direction onto the clean Si and the Au substrate at very low magnetic forces (0.02-0.89 T) at room temperature The successful alignment of the SWNTs with multi-layer film was observed by SEM and TEM. By changing the orientation and location of the substrates, crossed-networks of SWNTs-magnetic particle complex could easily be fabricated. It is suggested that this approach, which consists of a combination of biol. interaction among streptavidin-biotin and magnetite particles, should be useful for lateral orientation of individual SWNTs with controllable direction.

Journal of Nanoscience and Nanotechnology published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Das, Rajesh published the artcileStrategic design of a bifunctional Ag(I)-grafted NHC-MOF for efficient chemical fixation of CO₂ from a dilute gas under ambient conditions, Synthetic Route of 258278-25-0, the publication is Inorganic Chemistry Frontiers (2022), 9(11), 2583-2593, database is CAplus.

The chem. fixation of carbon dioxide into valuable products constitutes a promising step toward reducing the atm. CO₂ concentration Consequently, herein we report the strategic design of a bifunctional catalyst by grafting catalytically active Ag(I) ions onto N-heterocyclic carbene (NHC) sites in a MOF for efficient chem. fixation of CO₂ from a dilute gas to oxazolidinones, bio-relevant commodity chems. Indeed, Ag(I)@MOF-NHC demonstrated excellent catalytic activity for efficient fixation of CO₂ from a dilute gas (CO₂ : N₂ = 13 : 87%) with alkynes to afford valuable chems., oxazolidinones, under RT and atm. pressure (balloon) conditions. The superior activity of the Ag(I) anchored MOF over the individual (AgNO₃ and MOF-NHC) components has been ascribed to the synergistic effect between the CO₂-philic NHC and alkynophilic Ag(I) sites exposed in the 1D channels of the MOF. Furthermore, the Ag(I) anchored MOF showed high recyclability without significant loss of catalytic activity and structural rigidity. Overall, this is a unique demonstration of the utilization of dilute CO₂ under environmentally friendly mild conditions and can pave the way for the development of efficient catalytic systems for sustainable utilization of CO₂ from dilute gases.

Inorganic Chemistry Frontiers published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Synthetic Route of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hamamoto, Hiroshi published the artcileSerum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus, SDS of cas: 359860-27-8, the publication is Nature Communications (2021), 12(1), 6364, database is CAplus and MEDLINE.

Lysocin E is a lipopeptide with antibiotic activity against methicillin-resistant Staphylococcus aureus. For unclear reasons, the antibacterial activity of lysocin E in a mouse systemic infection model is higher than expected from in vitro results, and the in vitro activity is enhanced by addition of bovine serum. Here, we confirm that serum from various species, including humans, increases lysocin E antimicrobial activity, and identify apolipoprotein A-I (ApoA-I) as an enhancing factor. ApoA-I increases the antibacterial activity of lysocin E when added in vitro, and the antibiotic displays reduced activity in ApoA-I gene knockout mice. Binding of ApoA-I to lysocin E is enhanced by lipid II, a cell-wall synthesis precursor found in the bacterial membrane. Thus, the antimicrobial activity of lysocin E is potentiated through interactions with host serum proteins and microbial components.

Nature Communications published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, SDS of cas: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Gang-Jian published the artcileNi/NHC-catalyzed cross-coupling of methyl sulfinates and amines for direct access to sulfinamides, Related Products of imidazoles-derivatives, the publication is Tetrahedron Letters (2019), 60(46), 151260, database is CAplus.

A simple and convenient method was developed for the Ni/NHC-catalyzed cross-coupling of Me sulfinates and amines without an acid/base to afford secondary or tertiary sulfinamides RS(O)NR¹R² [R = Me, c-hexyl, 4-MeC₆H₄, etc.; R¹ = Et, CH₂CH=CH₂, Bn, etc.; R² = H, Me, Et, etc.; R¹R² = (CH₂)₄, (CH₂)₂O(CH₂)₂, (CH₂)₂S(CH₂)₂, etc.] in moderate to good yields. The method provided the desired products with broad substrate scope, good chemoselectivity and good functional group compatibility.

Tetrahedron Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Algul, Oztekin published the artcileSynthesis, characterization and genotoxicity of platinum(II) complexes with substituted benzimidazole ligands, Application In Synthesis of 7467-35-8, the publication is Turkish Journal of Chemistry (2005), 29(6), 607-615, database is CAplus.

Five cis-[Pt(II)Cl₂L_n] complexes with substituted benzimidazole ligands (n = 2, L = 2-ethyl-, 2-benzyl-, 2-phenoxymethyl-, 1-methyl-2-phenyl-benzimidazole; n = 1, L = 1-methyl-2-hydroxymethylbenzimidazole) were synthesized and characterized by elemental anal., and IR and ¹H-NMR spectra and evaluated for their in vitro genotoxic activities by Rec-Assay test. Based on the data obtained the Pt(II) complexes tested might be taken into consideration as promising antitumor compounds

Turkish Journal of Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application In Synthesis of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Smith, Leon M. II published the artcileNovel phenylalanine derived diamides as Factor XIa inhibitors, Application In Synthesis of 13682-33-2, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(2), 472-478, database is CAplus and MEDLINE.

The synthesis, structural activity relationships (SAR), and selectivity profile of a potent series of phenylalanine diamide FXIa inhibitors will be discussed. Exploration of P1 prime and P2 prime groups led to the discovery of compounds with high FXIa affinity, good potency in our clotting assay (aPPT), and high selectivity against a panel of relevant serine proteases as exemplified by compound (I). Compound I demonstrated good in vivo efficacy (EC₅₀ = 2.8 μM) in the rabbit elec. induced carotid arterial thrombosis model (ECAT).

Bioorganic & Medicinal Chemistry Letters published new progress about 13682-33-2. 13682-33-2 belongs to imidazoles-derivatives, auxiliary class Imidazole,Amine,Benzene, name is 4-(1H-Imidazol-2-yl)aniline, and the molecular formula is C10H9NO4S, Application In Synthesis of 13682-33-2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem