Month: December 2022

Albrecht, Markus published the artcileStructures and properties of complexes [MCl(C₅Me₅)(N-S)](PF₆), M = Rh, Ir, with N-S = 1-methyl-2-(alkylthiomethyl)-1H-benzimidazole ligands, Application of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Journal of Organometallic Chemistry (2000), 596(1-2), 84-89, database is CAplus.

The four complexes [MCl(C₅Me₅)(N-S)](PF₆), M = Rh, Ir; N-S = 1-methyl-2-(methylthiomethyl)-1H-benzimidazole (mmb) and 1-methyl-2-(tert-butylthiomethyl)-1H-benzimidazole (mtb) were synthesized and characterized by spectroscopy, electrochem. and x-ray crystallog. (as MeOH solvates). The essential coordination features, viz., longer M-S (∼2.38 A) and shorter M-N bonds (∼2.09 A) in five-membered chelate rings are common to all four species. Cyclic voltammetry reveals irreversible two-electron reduction to M^I complexes and partially reversible oxidation to Ir^IV species for [IrCl(C₅Me₅)(mtb)]⁺. The results are discussed in comparison with those obtained for α-diimine (N-N) complexes of the [MCl(C₅Me₅)]⁺ fragments.

Journal of Organometallic Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Application of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cauwenbergh, Thibault published the artcileContinuous Flow Synthesis of Sulfur- and Selenium-NHC Compounds (NHC=N-Heterocyclic Carbene), Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is European Journal of Organic Chemistry (2022), 2022(15), e202101296, database is CAplus.

The first continuous flow syntheses of sulfur- and selenium-NHC (NHC=N-heterocyclic carbene) adducts in unprecedented short reaction times and high yields are reported. The importance of these species in coordination chem. or as efficient tools for determining the π-acceptor character of NHC ligands make any improvement in their synthesis a worthy goal. Thiourea derivatives bearing both saturated and unsaturated NHCs were obtained using NEt3 as a weak base (homogeneous setup) in conjunction with a bed of elemental sulfur (S₈). The synthetic route proving optimal for selenoureas involves the use of a simple Se/K₂CO₃ heterogeneous microreactor design.

European Journal of Organic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sutar, Suraj M. published the artcilePalladium Catalyzed Electrophilic C2-Arylation of Azoles by Aryltriazenes in Ionic Liquid Promoted by Acidic Ionic Liquid, Quality Control of 2622-67-5, the publication is ChemistrySelect (2020), 5(39), 12324-12327, database is CAplus.

A green C-H bond activation of azole based bio-pertinent substrates such as benzoxazole, benzothiazole, benzimidazole, etc. are accomplished using readily prepared 1-aryltriazenes RN=NNR¹R² (R = C₆H₅, 4-CH₃C₆H₄, 4-ClC₆H₄, etc.; R¹ = R² = Et; R¹R² = -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-) as arylating agent. Under an optimized condition employing Pd(OAc)₂ and CuI in either hydrophilic [Bmim][BF₄] or hydrophobic [Bmim][PF₆] IL medium with [BMIM(SO₃H)][OTf] as a promoter, these arylation reactions proceeded smoothly to afford 2-aryl substituted azoles I (X = O, S, NCH₃, NC₆H₅, 4-CH₃C₆H₄N; R³ = H, Me; R⁴ = H, NH₂, Cl, CH₃) and 2-(p-tolyl)thiazole in acceptable to better yields besides noticeable functional group tolerance. The prospective for recovery and re-use of ionic liquid solvent is demonstrated.

ChemistrySelect published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C9H11BO4, Quality Control of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sitzius, Hannelore published the artcileMass spectrometric studies of 4(5)-hydroxymethylimidazoles, Application In Synthesis of 45533-87-7, the publication is Archiv der Pharmazie (Weinheim, Germany) (1979), 312(12), 994-1003, database is CAplus.

The mass spectra of 11 I (R, R¹ = H, Me; R² = H, Me, cyclohexyl, p-tolyl, PhCH₂CH₂, Et, Pr) and of II are described and schemes for the fragmentation of I (R = R¹ = R² = H) and II are given.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C10H12F6N4O6PdS2, Application In Synthesis of 45533-87-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhou, Bingwei published the artcileIron-Catalyzed Remote Arylation of Aliphatic C-H Bond via 1,5-Hydrogen Shift, Quality Control of 258278-25-0, the publication is ACS Catalysis (2018), 8(1), 8-11, database is CAplus.

Catalytic amounts of an iron(III) salt and a N-heterocyclic carbene ligand catalyze the arylation of 2-iodoalkylarenes with diphenylzinc selectively at the γ C-H bond of the alkyl side chain. Several lines of evidence suggest that the iron catalyst reacts with the aryl iodide moiety of the substrate to generate an aryliron intermediate that behaves in a radical manner and cleaves the aliphatic C-H bond through 1,5-hydrogen transfer; the resulting alkyliron intermediate undergoes reductive elimination to give the arylated product.

ACS Catalysis published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C8H5IO, Quality Control of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Ying published the artcileA simple and efficient one step synthesis of benzoxazoles and benzimidazoles from carboxylic acids, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Tetrahedron Letters (2006), 47(28), 4823-4826, database is CAplus.

Benzoxazoles or benzimidazoles can be rapidly and efficiently synthesized from a variety of carboxylic acids with 2-aminophenols or 1,2-phenylenediamines in one simple step, resp. The use of com. available PS-PPh₃ resin combined with microwave heating delivered a variety of benzoxazoles and benzimidazoles in high yields and purities.

Tetrahedron Letters published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C16H18Br2ClN3O3, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cooley, Michaela published the artcileInfluence of particle size and shape on their margination and wall-adhesion: implications in drug delivery vehicle design across nano-to-micro scale, Application of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Nanoscale (2018), 10(32), 15350-15364, database is CAplus and MEDLINE.

Non-spherical particles theor. have a higher area of surface-adhesive interactions than spherical particles. However, detailed systematic studies that integrate various particle size and shape parameters across nano-to-micro scale to explore their wall-localization behavior in RBC-rich blood flow, have not been reported. In this study we address this gap by carrying out computational and exptl. studies utilizing particles of four distinct shapes spanning nano- to-micro scale sizes. Computational studies were performed using the LAMMPS package, with Dissipative Particle Dynamics. For exptl. studies, model particles were made from neutrally buoyant fluorescent polystyrene spheres, that were thermo-stretched into non-spherical shapes and all particles were surface-coated with biotin. Using microfluidic setup, the biotin-coated particles were flowed over avidin-coated surfaces in absence vs. presence of RBCs, and particle adhesion and retention at the surface was assessed by inverted fluorescence microscopy. Our computational and exptl. studies provide a simultaneous anal. of different particle sizes and shapes for their retention in blood flow and indicate that in presence of RBCs, micro-scale non-spherical particles undergo enhanced ‘margination + adhesion’ compared to nano-scale spherical particles, resulting in their higher binding. These results provide important insight regarding improved design of vascularly targeted drug delivery systems.

Nanoscale published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Application of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hernandez, Elisa published the artcileUniversal and low energy-demanding platform to produce propylene carbonate from CO₂ using hydrophilic ionic liquids, Application of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Separation and Purification Technology (2022), 121273, database is CAplus.

Ionic liquids (ILs) have been extensively proposed as efficient catalysts to promote CO₂ cycloaddition reaction to epoxides for producing cyclic carbonates. Recently, liquid-liquid extraction with water as an enhancer approach to regenerate ILs and to purify the product was proposed, since it reduces energy consumption and enhances the neat catalytic activity of the IL due to hydroxyl groups of water. In this work, a comprehensive sample of homogeneous IL catalysts proposed in the literature is exptl. evaluated both in the catalytic step and in its separation by liquid-liquid extraction with water, to demonstrate the universality of the proposed reaction-separation proposal for hydrophilic ILs. Then the complete processes for CO₂ conversion to propylene carbonate were modelled using Aspen Plus to compare the catalyst/product separation efficiency and the specific energy consumption using liquid-liquid extraction and distillation-based platforms. The energy consumption is significantly lower using liquid-liquid platform (1.1-1.3 kWh/kg_PC) than distillation one (2.4-3.1 kWh/kg_PC). It is concluded that hydrophilic ionic liquids, as those formed by [EtOHmim] cation and halide anions, are promising catalysts since they allow: (i) reducing the process energy consumption due to their high catalytic activity and (ii) full catalyst recovering, even at high catalyst loadings, by improving the water extractive properties for IL separation from PC.

Separation and Purification Technology published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Application of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Gullotti, Michele published the artcileSynthesis and characterization of new chiral octadentate nitrogen ligands and related copper(II) complexes as catalysts for stereoselective oxidation of catechols, COA of Formula: C9H9ClN2, the publication is Journal of Molecular Catalysis A: Chemical (2005), 235(1-2), 271-284, database is CAplus.

Three new octadentate ligands, namely (R)-N,N’-dimethyl-N,N’-bis{3-[bis(1-methyl-2-imidazolylmethyl)]aminopropyl}-1,1′-binaphthyl-2,2′-diamine, (R)-DABN-3Im₄, (R)-N,N’-dimethyl-N,N’-bis{4-[bis(1-methyl-2-benzimidazolylmethyl)]aminobutyl}-1,1′-binaphthyl-2,2′-diamine, (R)-DABN-4Bz₄, and (S)-N2,N6-dimethyl-N2,N6-bis{2′-[bis(1-methyl-2-benzimidazolylmethyl)]aminomethyl}benzyl-2,6-diamino-1-hexanol acetate, -Lys-4Bz₄, were employed for the synthesis of dinuclear and trinuclear copper(II) complexes. The ligands contain two side arms of different nature and length which carry tridentate aminobis(benzimidazole) or aminobis(imidazole) residues as metal binding sites (A sites) connected to a central (R)-1,1′-binaphthyl-2,2′-diamine or -lysine residue which can bind a third metal ion (B site). The chiroptical properties of the ligands and the complexes have been described. The complexes were tested as catalysts in the oxidation of 3,5-di-tert-butylcatechol, L-, D-Dopa and L-, D-Dopa Me esters by dioxygen to give the corresponding quinones. The catalytic efficiency is moderate, but the complexes exhibit significant enantio-differentiating ability towards L-, D-Dopa Me esters, albeit their enantio-differentiating ability towards L-, D-Dopa is lower. The (R)-1,1′-binaphthyl-2,2′-diamine spacer in the (R)-DABN complexes has much stronger recognition power than the aliphatic L-lysine spacer in the L-Lys complexes. In addition, the highest stereoselectivity in the catalytic oxidation is obtained with the (R)-DABN-3Im₄ complexes, containing carbon chains of three atoms between the (R)-1,1′-binaphthyl-2,2′-diamine groups and the tridentate donor units at the A metal binding sites. In all cases, the preferred enantiomeric substrate has the configuration, which is dictated by the chirality of the spacer residue.

Journal of Molecular Catalysis A: Chemical published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, COA of Formula: C9H9ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sane, R. T. published the artcileExtractive spectrophotometric determination of antazoline hydrochloride, maphazoline nitrate, xylometazoline hydrochloride and tetrahydrozoline hydrochloride, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Indian Drugs (1979), 16(10), 239-41, database is CAplus.

A direct spectrophotometric method for the quant. determination of antazoline-HCl (I) [2508-72-7], naphazoline nitrate [5144-52-5], xylometazoline-HCl [1218-35-5], and tetrahydrozoline-HCl [522-48-5] is described. The method is based on the formation of colored complexes between these compounds and bromocresol green, bromophenol blue, bromothymol blue, and methyl orange. The complexes formed can be extracted in chloroform.

Indian Drugs published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem