Syntheses of some nitroimidazole substituted boronic acids: precursors to technetium-99m complexes with potential for imaging hypoxic tissue was written by Raju, N.;Ramalingam, K.;Nowotnik, D. P.. And the article was included in Tetrahedron in 1992.Category: imidazoles-derivatives This article mentions the following:
A number of nitroimidazole-substituted alkyl- and arylboronic acids I (R = NO2, R1 = H, X = C6H4-4, CH2C6H4-4, CH2CH2, CH(OH)CH2OCH2C6H4-4, CONHCH2C6H4-4; R = H, Me, R1 = NO2, X = C6H4-4) were synthesized as precursors to 99mTc complexes under investigation as potential imaging agents of hypoxia. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Category: imidazoles-derivatives).
2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Category: imidazoles-derivatives
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem