Production of silk fibroin nanoparticles using ionic liquids and high-power ultrasounds was written by Abel Lozano-Perez, Antonio;Montalban, Mercedes Garcia;Aznar-Cervantes, Salvador David;Cragnolini, Francesca;Cenis, Jose Luis;Villora, Gloria. And the article was included in Journal of Applied Polymer Science in 2015.Reference of 79917-89-8 This article mentions the following:
Biopolymeric nanoparticles have attracted great research interest in the last few years due to their multiple applications. This article describes how high-power ultrasounds are capable of enhancing the dissolution process of silk proteins in ionic liquids (ILs) and how silk fibroin nanoparticles (SFNs) can be obtained directly from the silk/ionic liquid solution (SIL) by rapid desolvation in polar organic solvents. The silk fibroin integrity is highly preserved during the dissolution process, as confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of the SIL. These regenerated SFNs are insoluble in water and other common organic solvents and are indistinguishable from the classical SFNs with respect to their diameter (180 ± 5 nm), Zeta potential (-25 ± 3 mV), high degree of β-sheet and low cytotoxicity. Large amounts of silk can be turned into biomaterials directly from the SIL solution for use in a wide range of applications, while the ILs can be recovered from the coagulant solution under reduced pressure and reused without loss of their solvent properties. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41702. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Reference of 79917-89-8).
1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 79917-89-8
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem