Zhong, Yong-Li published the artcileNew Method for the Synthesis of Diversely Functionalized Imidazoles from N-Acylated α-Aminonitriles, Related Products of imidazoles-derivatives, the publication is Organic Letters (2004), 6(6), 929-931, database is CAplus and MEDLINE.
A new general method for the synthesis of medicinally important diversely functionalized imidazoles from N-acylated α-aminonitriles has been developed. N-Acylated α-aminonitriles were reacted with triphenylphosphine and carbon tetrahalide to afford 2,4-disubstituted 5-halo-1H-imidazoles in good yield. This new methodol. was applied for the synthesis of 2-butyl-4-chloro-5-hydroxymethylimidazole. These haloimidazoles can be directly converted to 2,4,5-trisubstituted imidazoles through palladium-catalyzed coupling reactions. The reaction of N-[1-cyano-2-(phenylmethoxy)ethyl]pentanamide (I) with carbon tetrachloride gave 2-butyl-4-chloro-5-[(phenylmethoxy)methyl]-1H-imidazole (II) which upon deprotection gave 2-butyl-5-chloro-1H-imidazole-4-methanol, a synthetic intermediate for cozaar.
Organic Letters published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C18H16N2O6, Related Products of imidazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem