Xue, Yang published the artcileNovel hypoglycemic compound-synthesis of glycine derivatives and research on the role of PPARs, SDS of cas: 4760-35-4, the publication is Jiefangjun Yaoxue Xuebao (2009), 25(1), 5-10, database is CAplus.
The aim of this paper is to synthesize five novel hypoglycemic glycine-type drugs and research the role of PPARs. The synthesis started with the reaction between 4-hydroxybenzaldehyde and 3-[4-phenoxyphenoxy] propanol, 2-(4-phenoxyphenoxy) ethanol, benzimidazole derivatives The resulting compounds were condensed with proper aldehyde to give Schiff bases. The imine derivatives reacted with 4-methoxyphenyl carbonochloridate, followed by hydrolysis, to give the desired glycine analogs. The target’s role in the activation of PPARs was determined The results showed that the 5 novel compounds were synthesized and characterized by 1HNMR. Targets show varying degrees of activation of PPARs. The bioassay indicated that five target compounds 6a, 6b, 6c, 6’a, 6’b were capable of activating PPARs. Among them, 6a, 6b, 6c are more effective. They can be good candidates for the therapy of insulin resistance and high blood sugar.
Jiefangjun Yaoxue Xuebao published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C7H7ClN2S, SDS of cas: 4760-35-4.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem