Sioriki, Eleni published the artcileIn vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds, Product Details of C27H39ClN2, the publication is ChemMedChem (2018), 13(23), 2484-2487, database is CAplus and MEDLINE.
The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC·H][AuCl2] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in anal. pure form. In addition, the biol. activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*·H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.
ChemMedChem published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C9H13NO2, Product Details of C27H39ClN2.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem