Hirohata, R.’s team published research in Proceedings of the International Congress of Biochemistry in | CAS: 45533-87-7

Proceedings of the International Congress of Biochemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Name: (2-Methyl-1H-imidazol-4-yl)methanol.

Hirohata, R. published the artcileSynthesis of ophidine, Name: (2-Methyl-1H-imidazol-4-yl)methanol, the publication is Proceedings of the International Congress of Biochemistry (1955), 20, database is CAplus.

Ophidine is an anserine-like compound from cobra muscle. Kendo (C.A. 45, 3438c) reported that it is β-alanyl-2-methylhistidine. To confirm this structure, 2-methyl-4(5)-hydroxymethylimidazole (I), m. 114°, was synthesized from NH4OH, fructose, and AcH. I was converted to the chloromethyl compound (II), m. 125°. AcNHCH(CO2Et)2 was condensed with II, yielding Et α-acetamido-α-carbethoxy-2-methyl-4(5)-imidazolepropionate (III), m. 122°. III was hydrolyzed and decarboxylated to 2-methylhistidine (IV), m. 231°, which was acetylated and resolved by means of acylase 1. The resulting L-IV with phthaloyl-β-alanyl chloride in the presence of NEt3 at -10° yielded phthaloyl-β-alanyl-2-methylhistidine (V), m. 240°. By treating V with N2H4.H2O solution 2 days, the phthaloyl group was detached, and β-alanyl-2-methylhistidine, m. 249°, was obtained. It gave no depression in m.p. when mixed with natural ophidine. Few exptl. details are given.

Proceedings of the International Congress of Biochemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Name: (2-Methyl-1H-imidazol-4-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem