Furukawa, Yoshiyasu published the artcileNonpeptide angiotensin II receptor antagonists. Synthetic studies on imidazoleacetic acid derivatives, Quality Control of 79047-41-9, the publication is Takeda Kenkyushoho (1991), 56-74, database is CAplus.
An improved synthetic route using 4-hydroxymethyl-2-phenylimidazole was developed for the synthesis of diuretic and angiotensin II-inhibitory CV-2198 (I, R = R1 = H) (II). This route achieved a facile synthesis of 2-alkyl-1-benzyl-4-chloroimidazole-5-acetic acids. Study of structure-activity relationships on the 10 compounds indicated that Bu, pentyl, and hexyl groups were favorable as the 2-alkyl groups and substitution by a Cl or NO2 group at the o-position of the benzyl moiety increased the activity. Thus, I (R = Bu, R1 = Cl) (CV-2947) and I (R = Bu, R1 = NO2) (CV-2961) had angiotensin II-inhibitory activity 100-fold stronger than that of II.
Takeda Kenkyushoho published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Quality Control of 79047-41-9.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem