Xia, Pin-si published the artcileDetermination of related substances in esomeprazole sodium for injection by RP-HPLC, Computed Properties of 161796-78-7, the publication is Zhongnan Yaoxue (2014), 12(11), 1131-1135, database is CAplus.
An RP-HPLC method to determine the related substances in esomeprazole sodium for injection was established. The determination was performed on a Inerstil ODS-3 column (150 mm×4.6 mm, 5 μm), with a mobile phase consisting of a mixture of acetonitrile and phosphate buffer (pH=7.4) and tetrabutylammonium hydrogen sulfate. The column temperature was 30°C at 1.0 mL·min-1 and the detective wavelength was 280 nm. The related substances were completely separated from the main constituent. Impurity A and B were stable in 24 h under the condition of frozen dark, but impurity C was not stable. Omeprazole and impurity A, B and C had good linearity at 0.0633-2.1108 μg·mL-1 (r=1.000), 0.1465-1.9538 μg·mL-1 (r=1.000), 0.1587-1.9835 μg·mL-1 (r=0.9999), 0.0576-3.8388 μg·mL-1 (r=0.9996) resp. The recoveries were at 91%-105%, and RSDs were less than 5%, which could be meet the requirements. The method can be used for the quality control of esomeprazole sodium for injection.
Zhongnan Yaoxue published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C4H5BN2O2, Computed Properties of 161796-78-7.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem