Sun, Qiao published the artcileCobalt-catalyzed C(sp2)-H/C(sp3)-H coupling via directed C-H activation and 1,5-hydrogen atom transfer, Synthetic Route of 258278-25-0, the publication is Organic Chemistry Frontiers (2018), 5(4), 582-585, database is CAplus.
The regioselective synthesis of 1-[2-[(benzylamino)methyl]phenyl]ethanones such as I [R = H, 3-Cl, 4-Ph, etc.; R1 = Me, n-Pr; R2 = Et, n-Bu; R1R2 = (CH2)3, (CH2)4, (CH2)5, etc.] via cobalt-catalyzed C(sp2)-H/C(sp3)-H cross-coupling reaction between various (E)-aryl imines and 2-bromobenzyl-protected secondary amines was reported. Promoted by a combination of a cobalt-N-heterocyclic carbene catalyst and Grignard reagent, the reaction was allowed for the introduction of α-aminoalkyl groups into the ortho position of the imine at a mild temperature The cobalt catalyst was proposed to play key roles in two distinct modes of C-H cleavage, i.e., directed C-H metalation and 1,5-hydrogen atom transfer.
Organic Chemistry Frontiers published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C7H5Cl2NO, Synthetic Route of 258278-25-0.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem