Rojsitthisak, Pornchai published the artcileSimple HPLC determination of benzalkonium chloride in ophthalmic formulations containing antazoline and tetrahydrozoline, COA of Formula: C17H20ClN3, the publication is PDA Journal of Pharmaceutical Science and Technology (2005), 59(5), 332-337, database is CAplus and MEDLINE.
A simple and rapid anal. procedure for routine quantification of n-C12H25 and n-C14H29 benzalkonium chloride (C-12 and C-14 BKC) homologs in ophthalmic formulations containing antazoline HCl and tetrahydrozoline HCl by high-performance liquid chromatog. was developed and validated. The ophthalmic solution samples can be directly analyzed by reversed-phase on HiQ-Sil C18 column (4.6 mm × 150 mm, i.d., 5-μm particle size) with acetonitrile-sodium acetate buffer (pH 5.0; 0.2 M) (70:30, volume/volume) as mobile phase. UV Detection was carried out at 262 nm. The method was linear over the selected concentration and ranged from 0.03 to 0.10 mg/mL (r2 = 0.9999) and from 0.01 to 0.05 mg/mL (r2 = 0.9979) for C-12 and C-14 BKC homologs, resp. The mean percent recoveries were 100.2 and 102.6 and the percent CV values were 1.3 and 3.5 for C-12 and C-14 BKC homologs, resp. The results demonstrated the good linearity, accuracy, and precision. The method was applied to determine 2 com. ophthalmic formulations, and the percent label amounts of total BKC contents were found to be 99.7 and 103.2.
PDA Journal of Pharmaceutical Science and Technology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, COA of Formula: C17H20ClN3.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
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