Maling, Harriet M. published the artcileInflammation induced by histamine, serotonin, bradykinin, and compound 48/80 in the rat. Antagonists and mechanisms of action, SDS of cas: 2508-72-7, the publication is Journal of Pharmacology and Experimental Therapeutics (1974), 191(2), 300-10, database is CAplus and MEDLINE.
A number of antagonists were tested for their ability to inhibit the inflammation induced by subplantar injection into the rat hindpaw of histamine-2HCl [56-92-8], serotonin creatinine sulfate [971-74-4], bradykinin [58-82-2],or compound 48-80. Triprolidine [486-12-4] and chlorpheniramine maleate [113-92-8] specifically inhibited histamine-induced edema. D-2-bromolysergic acid diethylamide [478-84-2] and methysergide [361-37-5] specifically inhibited serotonin-induced edema. Tripelennamine-HCl [22306-05-4], pyrilamine maleate [59-33-6], promethazine-HCl [58-33-3], antazoline-HCl [2508-72-7] diphenylhydramine-HCl [147-24-0], phenindamine tartrate [569-59-5], chlorcyclizine-HCl [14362-31-3] and l-isoproterenol-HCl [5984-95-2] inhibited the edemas induced by either serotonin or histamine. Promethazine, antazoline, diphenhydramine and l-isoproterenol also partially blocked the edema induced by bradykinin. Cyproheptadine-HCl [969-33-5] inhibited the edemas induced by both serotonin and bradykinin. By means of specific antagonists, the edema induced by compound 48/80 was shown to be due to the release of serotonin (65%) and histamine (30%). Kinins are probably not involved. In doses as low as 0.005 μmol/kg s.c., l-isoproterenol inhibited compound 48/80-induced edema. Some antihistamines, especially tripelennamine, inhibited compound 48/80 edema more effectively than could be explained by their inhibition of either histamine or serotonin. Their effectiveness was correlated with their abilities to inhibit the release of mediators from isolated rat peritoneal mast cells.
Journal of Pharmacology and Experimental Therapeutics published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, SDS of cas: 2508-72-7.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem