Li, Ting-ting published the artcileRP-HPLC determination of related substances of esomeprazole sodium, Formula: C17H18N3NaO3S, the publication is Yaowu Fenxi Zazhi (2013), 33(4), 656-660, database is CAplus.
A reversed-phase high-performance liquid chromatog. (RP-HPLC) method was established for the determination of related substances of esomeprazole sodium. The determination was performed on a Venusil XBP C18 (L) column (250 mm × 4.6 mm, 5 μm), with a mobile phase consisting of a mixture of acetonitrile and phosphate buffer (pH 7.6) by gradient elution. The column temperature was set at 30°C with a flow rate of 0.8 mL·min-1, and the detective wavelength was 302 nm. The related substances were completely separated from the main constituent. The calibration curves for 5-methoxy-2-mercaptobenzimidazole, omeprazole sulfone N-oxide, omeprazole sulfone, esomeprazole sodium and omeprazole sulfide revealed good linearities over the ranges of 3.99-29.94 μg·mL-1 (r=0.9998), 4.06-30.45 μg·mL-1 (r=0.9999), 2.46-18.42 μg·mL-1 (r=0.9998), 3.96-29.67 μg·mL-1 (r=0.9994), and 4.08-31.32 μg·mL-1 (r=0.9998), resp. The recoveries of the above compounds were 99.5% with RSD of 0.6%, 99.1% with RSD of 0.3%, 99.0% with RSD of 0.6%, 99.2% with RSD of 0.9%, and 99.0% with RSD of 0.7%, resp. The method could be used for testing the product quality of esomeprazole sodium.
Yaowu Fenxi Zazhi published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Formula: C17H18N3NaO3S.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem