Huang, Shuai published the artcilePd-Catalyzed umpolung asymmetric allylic alkylation of hydrazones to vicinal tertiary and quaternary chiral carbon centers, Quality Control of 258278-25-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(21), 3513-3516, database is CAplus and MEDLINE.
Diastereo- and enantioselective construction of vicinal tertiary and quaternary carbon centers is a great challenge in synthetic chem. Herein, a facile and efficient protocol to construct unsaturated azo compounds I [R1 = Ph, 4-FC6H4, 2-naphthyl, 2-thienyl, etc., R2 = Me; R1 = Ph, R2 = Et; R1R2 = (CH2)5; R3 = Ph, 4-MeOC6H4, 1,3-benzodioxol-5-yl, 2-furyl, etc.] with vicinal tertiary and quaternary chiral carbon centers in high yields with high regio-, diastereo- and enantioselectivities via Pd-catalyzed umpolung asym. allylic alkylation of hydrazones II with monosubstituted allylic pivalates R3CH:CHCH2OC(O)Bu-t by using Kundig-type chiral N-heterocyclic carbene as the ligand is reported. The control experiments revealed that the reaction proceeds via the inner-sphere mechanism.
Chemical Communications (Cambridge, United Kingdom) published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Quality Control of 258278-25-0.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem