Hu, Zhiyuan published the artcileI2-Mediated Intramolecular C-H Amidation for the Synthesis of N-Substituted Benzimidazoles, Application In Synthesis of 2622-67-5, the publication is Journal of Organic Chemistry (2017), 82(6), 3152-3158, database is CAplus and MEDLINE.
A practical intramol. C-H amidation methodol. has been developed using mol. iodine under basic conditions. The required imine substrates were readily obtained by condensation of simple o-phenylenediamine derivatives and aldehydes. The transition-metal-free cyclization reaction described here works well with crude imines and allows for the sequential synthesis of N-protected 2-substituted benzimidazoles without purification of the less stable condensation intermediates. This operationally simple synthetic approach is broadly applicable to a variety of aromatic, aliphatic, and cinnamic aldehydes to produce diverse 1,2-disubstituted benzimidazole derivatives in an efficient and scalable fashion.
Journal of Organic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Application In Synthesis of 2622-67-5.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem