Chen, Tao’s team published research in Huaxue Shiji in 37 | CAS: 120118-14-1

Huaxue Shiji published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C11H8ClN3, Product Details of C11H8ClN3.

Chen, Tao published the artcileSynthesis of 4(5)-chloro-2-cyano-5(4)-(4-methylphenyl)imidazole, Product Details of C11H8ClN3, the publication is Huaxue Shiji (2015), 37(6), 571-573, database is CAplus.

Compound 4-chloro-2-cyano-5-(4-methylphenyl)imidazole was synthesized from 4-methylacetophenone. It started from oxidation using selenium dioxide and cyclization by hydroxylamine and glyoxal solution to give 4-hydro-5-(4-methylphenyl)-2-oxyiminomethylimidazole-3-oxide as the key intermediate. Then, the process was followed by dehydration and chlorination with thionyl chloride and N,N-dimethylformamide. The overall yield was 69.0% (based on 4′-methylacetophenone).

Huaxue Shiji published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C11H8ClN3, Product Details of C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem